ArticleScientific reports2020
Protein-protein interaction of the putative magnetoreceptor cryptochrome 4 expressed in the avian retina.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed.
- Decoding the Oncogenic Role of GNG10 in Colorectal Cancer: A Non-Canonical Wnt Pathway-Driven Mechanism.Journal of cellular and molecular medicine · 2026Article
- A Charge-Reversal Point Mutation Completely Depletes Flavin Chromophore from European Robin Cryptochrome 4a Protein.The journal of physical chemistry letters · 2026Article
- From skylight cues to magnetic fields: the toolkit of insect long-distance navigation.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Spectroscopic Characterization of Radical Pair Photochemistry in Nonmigratory Avian Cryptochromes: Magnetic Field Effects inJournal of the American Chemical Society · 2025Article
- European Robin Cryptochrome-4a Associates with Lipid Bilayers in an Ordered Manner, Fulfilling a Molecular-Level Condition for Magnetoreception.ACS chemical biology · 2025Article
- AAV-mediated transduction of songbird retina.Frontiers in physiology · 2025Article
- From Wings to Wellness: A Research Agenda Inspired by Migratory Bird Adaptations for Sleep and Circadian Medicine.Nature and science of sleep · 2025Article
- Magnetic sense-dependent probabilistic decision-making in humans.Frontiers in neuroscience · 2025Article
- Cryptochrome magnetoreception: Time course of photoactivation from non-equilibrium coarse-grained molecular dynamics.Computational and structural biotechnology journal · 2024Article
- Comparison of retinol binding protein 1 with cone specific G-protein as putative effector molecules in cryptochrome signalling.Scientific reports · 2024Article
- Adaptive evolution and loss of a putative magnetoreceptor in passerines.Proceedings. Biological sciences · 2024Article
- Dimerization of European Robin Cryptochrome 4a.The journal of physical chemistry. B · 2023Article
- Upper bound for broadband radiofrequency field disruption of magnetic compass orientation in night-migratory songbirds.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Probing Transcriptional Crosstalk betweenInternational journal of molecular sciences · 2023Article
- Isotope Substitution Effects on the Magnetic Compass Properties of Cryptochrome-Based Radical Pairs: A Computational Study.The journal of physical chemistry. B · 2023Article
- Magnetic field effects on radical pair reactions: estimation ofPhysical chemistry chemical physics : PCCP · 2023Article
- Kinetics of cone specific G-protein signaling in avian photoreceptor cells.Frontiers in molecular neuroscience · 2023Article
- Across atoms to crossing continents: Application of similarity measures to biological location data.PloS one · 2023Article
- Magnetoreceptory Function of European Robin Retina: Electrophysiological and Morphological Non-Homogeneity.Cells · 2022Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migratory birds can sense the Earth's magnetic field and use it for orientation over thousands of kilometres. A light-dependent radical-pair mechanism associated with the visual system is currently discussed as the underlying mechanism of the magnetic compass sense. The blue light receptor cryptochrome 4 (Cry4) is considered as the most likely primary sensory protein that detects the geomagnetic field. Since the protein interaction partners of Cry4 are completely unknown at present, here, we aim to identify potential candidate interaction partners of Cry4 in the avian retina. We used the yeast-two-hybrid system to screen avian cDNA libraries for possible interaction partners of Cry4 in the European robin. The UAS-GAL yeast two hybrid system was applied to confirm a group of candidate Cry4 interaction partners. Six proteins were found to be particularly promising candidates for interacting with European robin Cry4. The identified genes code for guanine nucleotide-binding protein G(t) subunit alpha-2 (GNAT2), long-wavelength-sensitive opsin (LWS, also called iodopsin), guanine nucleotide-binding protein subunit gamma 10 (GNG10), potassium voltage-gated channel subfamily V member 2 (KCNV2), retinol binding protein 1 (RBP1) and retinal G protein-coupled receptor (RGR). All genes are known to be expressed in vertebrate retinae of different species. We conclude by discussing putative signalling pathways that could connect cryptochrome 4 to one or more of these 6 candidates.
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