ArticleScience (New York, N.Y.)2020
Interleukin-13 drives metabolic conditioning of muscle to endurance exercise.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 129 citations in OpenAlex.
- Effect of physical training on cytokine expression in CD4+ T lymphocytes in subjects with stable COPD.Therapeutic advances in respiratory diseaseTrial
- Two-Way Communication Between Skeletal Muscle and Myokines.Cell biochemistry and function · 2026Review
- Circadian biology and exercise: the time to move.Life metabolism · 2026Review
- STAT Signaling in Metabolic Disorders: From Molecular Mechanisms to Therapeutic Implications.Cell biochemistry and biophysics · 2026Review
- Hepatocyte estrogen-related receptor α modulates a gluconeogenic-epigenetic crosstalk counteracting MASLD/MASH progression.Experimental & molecular medicine · 2026Article
- Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging.Nature immunology · 2026Article
- Metabolic Dysfunction-Associated Steatotic Liver Disease and Sarcopenia: Review of Literature.Journal of clinical medicine · 2026Review
- Cross-Platform Transcriptomic Analysis of 40 Human and Rodent Skeletal Muscle Exerkines.Muscles (Basel, Switzerland) · 2026Review
- Role of Peptides in Skeletal Muscle Wasting: A Scoping Review.Journal of cachexia, sarcopenia and muscle · 2025Article
- Single-nucleus RNA sequencing reveals RUNX1 regulation of muscle hypertrophy through PI3K/AKT/mTOR pathway.iMeta · 2025Article
- Role of the Th2-like Immune Response in Obesity: IL-4 as a Metabolic Regulator and IL-13 as an Effector of Muscle Energy Metabolism.Biomedicines · 2025Review
- Tumor cells upregulate neurotransmitter GABA in the choroid plexus through STAT6-Bestrophin1 signaling, promoting leptomeningeal dissemination.Neuro-oncology · 2025Article
- Primate retroelement exonization and sexually dimorphicScience immunology · 2025Article
- IL-13 priming in precursors drives beige adipogenesis and enhances metabolic homeostasis.The Journal of clinical investigation · 2025Article
- Preadipocyte IL-13/IL-13Rα1 signaling regulates beige adipogenesis through modulation of PPARγ activity.The Journal of clinical investigation · 2025Article
- Exercise-induced CLCF1 attenuates age-related muscle and bone decline in mice.Nature communications · 2025Article
- Article
- Creation of knockin mice for the fluorescence protein based in vivo identification of skeletal myofiber types.Scientific reports · 2025Article
- Stabilization Splint Therapy for Patients with Temporomandibular Disorders Improves Opening Movements and Jaw Limitation and Attenuates Pain by Influencing the Levels of IL-7, IL-8, and IL-13 in the Gingival Crevicular Fluid.Medicina (Kaunas, Lithuania) · 2025Article
- Eosinophils Respond to Extracellular Matrix Treated Muscle Injuries but are Not Required for Macrophage Polarization.Advanced healthcare materials · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors at 6 institutions in 1 country.
Nelson H KnudsenDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-0384-1097
Kristopher J StanyaDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-5369-729X
Alexander L HydeDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Mayer M ChalomDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0001-7852-9586
Ryan K AlexanderDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-9204-9586
Yae-Huei LiouDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0001-6758-7318
Kyle A StarostDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0003-4705-958X
Matthew R GanglDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
David JacobiDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0001-8674-223X
Sihao LiuDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Danesh H SopariwalaMetabolic and Degenerative Diseases, Institute of Molecular Medicine, University of Texas McGovern Medical School, Houston, TX 77030, USA.
Diogo Fonseca-PereiraDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-7400-9804
Jun LiDepartment of Nutrition and Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0003-3519-8638
Frank B HuDepartment of Nutrition and Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Wendy S GarrettDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-5092-0150
Vihang A NarkarMetabolic and Degenerative Diseases, Institute of Molecular Medicine, University of Texas McGovern Medical School, Houston, TX 77030, USA.ORCID 0000-0001-5574-083X
Eric A OrtlundEmory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0001-8855-3029
Jonathan H KimEmory University School of Medicine, Atlanta, GA 30322, USA.
Chad M PatonDepartment of Foods and Nutrition, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0001-8356-5303
Jamie A CooperDepartment of Foods and Nutrition, University of Georgia, Athens, GA 30602, USA.
Chih-Hao LeeDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA. clee@hsph.harvard.edu.ORCID 0000-0002-6090-0786
Harvard University · USThe University of Texas Health Science Center · USUniversity of Georgia · USBrigham and Women's Hospital · USEmory Healthcare · USEmory University · US
Funding
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI ROSEN, EVAN D · 1992 to 2021
$25.0MRegulation of angiogenesis by nuclear receptors and cofactorsR01HL129191 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI NARKAR, VIHANG A · 2015 to 2018
$1.7MCellular signaling in muscle metabolic adaptation and energy metabolismR01DK113791 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI LEE, CHIH-HAO · 2017 to 2019
$1.3MBioenergetic control in immune cell functionR21AI131659 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI LEE, CHIH-HAO · 2018 to 2019
$438kBmal1 and Hif1alpha partition metabolic regulation in inflammatory macrophagesF31GM117854 · NIGMS · HARVARD MEDICAL SCHOOL · PI ALEXANDER, RYAN K · 2016 to 2018
$100kImmune signaling in skeletal muscle oxidative metabolismF31DK107256 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI KNUDSEN, NELSON HOWARD · 2015 to 2017
$68kNHLBI NIH HHS R01 HL129191NIAID NIH HHS R21 AI131659NIDDK NIH HHS F31 DK107256NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK113791NIGMS NIH HHS F31 GM117854
Abstract
Repeated bouts of exercise condition muscle mitochondria to meet increased energy demand-an adaptive response associated with improved metabolic fitness. We found that the type 2 cytokine interleukin-13 (IL-13) is induced in exercising muscle, where it orchestrates metabolic reprogramming that preserves glycogen in favor of fatty acid oxidation and mitochondrial respiration. Exercise training-mediated mitochondrial biogenesis, running endurance, and beneficial glycemic effects were lost in
Indexed as
Adaptation, PhysiologicalAnimalsBlood GlucoseCell LineFatty AcidsFemaleGlycogenHumansInterleukin-13Interleukin-13 Receptor alpha1 SubunitMaleMiceMice, Inbred C57BLMice, KnockoutMitochondria, MuscleMuscle, SkeletalBlood GlucoseFatty AcidsGlycogenInterleukin-13Interleukin-13 Receptor alpha1 SubunitStat3 protein, mouseSTAT3 Transcription Factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.