ArticleProceedings of the National Academy of Sciences of the United States of America2020
Rapid topographic reorganization in adult human primary visual cortex (V1) during noninvasive and reversible deprivation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Advances in behavioral vision training for the treatment of childhood amblyopia: a narrative review.Translational pediatrics · 2026Review
- The impact of simulated cataract on face learning.Scientific reports · 2025Article
- Cortical response to transient and long-term visual field loss.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Virtual embodiment for improving range of motion in patients with movement-related shoulder pain: an experimental study.Journal of orthopaedic surgery and research · 2023Article
- Cortical Visual Impairment in Childhood: 'Blindsight' and the Sprague Effect Revisited.Brain sciences · 2021Review
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Can the primary visual cortex (V1), once wired up in development, change in adulthood? Although numerous studies have demonstrated topographic reorganization in adult V1 following the loss of bottom-up input, others have challenged such findings, offering alternative explanations. Here we use a noninvasive and reversible deprivation paradigm and converging neural and behavioral approaches to address these alternatives in the experimental test case of short-term topographic reorganization in adult human V1. Specifically, we patched one eye in typical adults, thereby depriving the cortical representation of the other eye's blind spot (BS), and immediately tested for topographic reorganization using functional magnetic resonance imaging and psychophysics. Strikingly, within just minutes of eye-patching, the BS representation in V1 began responding to stimuli presented outside of the BS, and these same stimuli were perceived as elongated toward the BS. Thus, we provide converging neural and behavioral evidence of rapid topographic reorganization in adult human V1, and the strongest evidence yet that visual deprivation produces bona fide cortical change.
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Registered trials
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