Evidence map›Paper›PMID 32354939›Full record

ArticleIn vivo (Athens, Greece)

Association of Genetic Polymorphisms With Afatinib-induced Diarrhoea.

Rintaro Sogawa, Chiho Nakashima, Tomomi Nakamura, Koji Takeuchi, Sakiko Kimura, Kazutoshi Komiya, Yutaka Narisawa, Shinya Kimura, Naoko Sueoka-Aragane

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Rintaro SogawaDepartment of Pharmacy, Saga University Hospital, Saga, Japan sogawari@cc.saga-u.ac.jp.
Chiho NakashimaDivision of Haematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Tomomi NakamuraDivision of Haematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Koji TakeuchiDepartment of Pharmacy, Saga University Hospital, Saga, Japan.
Sakiko KimuraDepartment of Pharmacy, Saga University Hospital, Saga, Japan.
Kazutoshi KomiyaDivision of Haematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Yutaka NarisawaDepartment of Pharmacy, Saga University Hospital, Saga, Japan.
Shinya KimuraDivision of Haematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Naoko Sueoka-AraganeDepartment of Pharmacy, Saga University Hospital, Saga, Japan.
Saga University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimAfatinib, a 2 PATIENTS AND

methodsWe evaluated the roles of four single nucleotide polymorphisms (SNPs) in ATP binding cassette subfamily B member 1 (ABCB1) and ATP binding cassette subfamily G member 2 (ABCG2) genes-ABCB1 1236 C>T, 2677 G>T/A, and 3435 C>T, and ABCG2 421 C>A-on treatment-induced diarrhoea in 38 patients with NSCLC treated with afatinib.

resultsDiarrhoea occurred more frequently in patients with ABCB1 2677 T(A)/T(A) (14/16, 87.5%) than in patients with non-T(A)/T(A) alleles (8/22, 36.4%) (p=0.003). ABCB1 2677 T(A)/T(A) was significantly predictive of diarrhoea (p=0.002) by multivariable regression analysis.

conclusionAfatinib-induced diarrhoea is associated with the SNP ABCB1 2677 T(A)/T(A).

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAfatinibAgedAged, 80 and overAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily G, Member 2DiarrheaFemaleHumansIncidenceMaleMiddle AgedNeoplasm ProteinsOdds RatioABCB1 protein, humanABCG2 protein, humanAfatinibAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily G, Member 2Neoplasm ProteinsProtein Kinase InhibitorsABCB1Afatinibdiarrhoeagenetic polymorphism

Identifiers

PMID32354939
PMCPMC7279839
OpenAlexW3023075739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.