Evidence map›Paper›PMID 32354886›Full record

ArticleIn vivo (Athens, Greece)

Augmentation of Neurotoxicity of Anticancer Drugs by X-Ray Irradiation.

Giichirou Nakaya, Hiroshi Sakagami, Yukari Koga-Ogawa, Akiyoshi Shiroto, Tadamasa Nobesawa, Daisuke Ueda, Sachie Nakatani, Kenji Kobata, Yosuke Iijima, Shigenobu Tone and 6 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Quantification ofIn vivo (Athens, Greece)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Giichirou NakayaFaculty of Health Sciences, Nihon Institute of Medical Science, Saitama, Japan.
Hiroshi SakagamiMeikai University School of Dentistry, Saitama, Japan sakagami@dent.meikai.ac.jp.
Yukari Koga-OgawaFaculty of Health Sciences, Nihon Institute of Medical Science, Saitama, Japan.
Akiyoshi ShirotoFaculty of Health Sciences, Nihon Institute of Medical Science, Saitama, Japan.
Tadamasa NobesawaFaculty of Health Sciences, Nihon Institute of Medical Science, Saitama, Japan.
Daisuke UedaFaculty of Health Sciences, Nihon Institute of Medical Science, Saitama, Japan.
Sachie NakataniGraduate School of Pharmaceutical Sciences, Josai University, Saitama, Japan.
Kenji KobataGraduate School of Pharmaceutical Sciences, Josai University, Saitama, Japan.
Yosuke IijimaSaitama Medical Center, Saitama Medical University, Saitama, Japan.
Shigenobu ToneGraduate School of Science and Engineering, Tokyo Denki University, Saitama, Japan.
Angel David-GonzalezNational School of Higher Education, Leon Unit, National Autonomous University of Mexico, Mexico City, Mexico.
Rene Garcia-ContrerasNational School of Higher Education, Leon Unit, National Autonomous University of Mexico, Mexico City, Mexico.
Mineko TomomuraMeikai University School of Dentistry, Saitama, Japan.
Shinji KitoMeikai University School of Dentistry, Saitama, Japan.
Nobuaki TamuraMeikai University School of Dentistry, Saitama, Japan.
Hiroshi TakeshimaMeikai University School of Dentistry, Saitama, Japan.
Meikai University · JPNihon Institute of Medical Science · JPJosai University · JPUniversidad Nacional Autónoma de México · MXSaitama Medical University · JPTokyo Denki University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn order to investigate the combination effect of anticancer drugs and X-ray irradiation on neurotoxic side-effects (neurotoxicity), a method that provides homogeneously X-ray-irradiated cells was newly established. MATERIALS AND

methodsPC12 cell suspension was irradiated by X-ray (0.5 Gy) in serum-supplemented medium, immediately inoculated into 96-microwell plates and incubated overnight. The medium was replaced with fresh serum-depleted medium containing 50 ng/ml nerve growth factor to induce differentiation toward nerve-like cells with characteristic neurites according to the overlay method without changing the medium. The differentiated cells were treated by anticancer drugs as well as antioxidants, oxaliplatin or bortezomib, and the viable cell number was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method.

resultsAntioxidants and anticancer drugs were cytotoxic to differentiating PC12 cells. Combination of anticancer drugs and X-ray irradiation slightly reduced cell viability.

conclusionThe present 'population irradiation method' may be useful for the investigation of the combination effect of X-ray irradiation and any pharmaceutical drug.

Indexed as

Radiation, IonizingX-RaysAnimalsAntineoplastic AgentsApoptosisBiomarkersCell Line, TumorCell SurvivalDisease Models, AnimalImmunohistochemistryMiceNervous SystemPhosphorylationSignal TransductionAntineoplastic AgentsBiomarkersneurotoxicityNGFPC12protective effectX-Ray irradiation

Identifiers

PMID32354886
PMCPMC7279790
OpenAlexW3021418700

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.