Evidence map›Paper›PMID 32354857›Full record

ArticleDiabetes2020

Maternal Obesity and Western-Style Diet Impair Fetal and Juvenile Offspring Skeletal Muscle Insulin-Stimulated Glucose Transport in Nonhuman Primates.

William Campodonico-Burnett, Byron Hetrick, Stephanie R Wesolowski, Simon Schenk, Diana L Takahashi, Tyler A Dean, Elinor L Sullivan, Paul Kievit, Maureen Gannon, Kjersti Aagaard and 2 more

Open access · greenAbstract read
In one paragraph

Article in Diabetes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 34 citations in OpenAlex.

  1. D-Fructose Exposure Impairs Neuronal Development in Mouse Neural Stem Cells.International journal of molecular sciences · 2026
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  15. High-fat diet during pregnancy promotes fetal skeletal muscle fatty acid oxidation and insulin resistance in an ovine model.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
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  20. Early life programming of health and disease: The long-term consequences of obesity in pregnancy.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

William Campodonico-BurnettDepartment of Human Physiology, University of Oregon, Eugene, OR.
Byron HetrickDepartment of Human Physiology, University of Oregon, Eugene, OR.
Stephanie R WesolowskiDepartment of Pediatrics, Perinatal Research Center, University of Colorado, Aurora, CO.
Simon SchenkDepartment of Orthopaedic Surgery, University of California, San Diego, La Jolla, CA.
Diana L TakahashiDivision of Cardiometabolic Health, Oregon National Primate Research Center, Oregon Health Science University, Beaverton, OR.
Tyler A DeanDivision of Cardiometabolic Health, Oregon National Primate Research Center, Oregon Health Science University, Beaverton, OR.
Elinor L SullivanDepartment of Human Physiology, University of Oregon, Eugene, OR.
Paul KievitDivision of Cardiometabolic Health, Oregon National Primate Research Center, Oregon Health Science University, Beaverton, OR.ORCID 0000-0003-1989-2478
Maureen GannonDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Kjersti AagaardDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX.
Jacob E FriedmanHarold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Carrie E McCurdyDepartment of Human Physiology, University of Oregon, Eugene, OR cmccurd5@uoregon.edu.ORCID 0000-0003-1177-9040
Oregon National Primate Research Center · USUniversity of Oregon · USBaylor College of Medicine · USUniversity of California San Diego · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Oklahoma Health Sciences Center · USVanderbilt University Medical Center · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3M
The Impact of Maternal Health and Diet on Development of Fetal Metabolic SystemsR24DK090964 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI AAGAARD, KJERSTI MARIE, FRIEDMAN, JACOB E · 2010 to 2019
$15.8M
UCHSC: Building Interdisciplinary Research Careers in Women's HealthK12HD057022 · NICHD · UNIVERSITY OF COLORADO DENVER · PI REGENSTEINER, JUDITH G., SANTORO, NANETTE F. · 2007 to 2023
$8.5M
Conserved Fetal Epigenomic Signatures in a Primate Model of Maternal ObesityR01DK089201 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI AAGAARD, KJERSTI MARIE · 2012 to 2021
$5.1M
Developmental Exposure to Maternal Obesity-Induced Inflammation Impacts Offspring Brain and Negative Valence BehaviorsR01MH107508 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI SULLIVAN, ELINOR L. · 2015 to 2019
$3.8M
The Colorado Building Interdisciplinary Research Careers in Women's Health ProgramK12AR084226 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI JUDITH G. REGENSTEINER, Nanette F. Santoro · 2023 to 2026
$2.5M
NIAMS NIH HHS K12 AR084226NICHD NIH HHS K12 HD057022NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK089201NIDDK NIH HHS R24 DK090964NIMH NIH HHS R01 MH107508
6 · The paper itself

Abstract

Infants born to mothers with obesity have a greater risk for childhood obesity and metabolic diseases; however, the underlying biological mechanisms remain poorly understood. We used a Japanese macaque model to investigate whether maternal obesity combined with a Western-style diet (WSD) impairs offspring muscle insulin action. Adult females were fed a control or WSD prior to and during pregnancy through lactation, and offspring subsequently weaned to a control or WSD. Muscle glucose uptake and signaling were measured ex vivo in fetal (

Indexed as

Diet, WesternAnimalsBiological TransportFemaleFetusGlucoseInsulinMacaca fuscataMuscle, SkeletalPhosphorylationPregnancyPregnancy in ObesityProto-Oncogene Proteins c-aktGlucoseInsulinProto-Oncogene Proteins c-akt

Identifiers

PMID32354857
PMCPMC7306120
OpenAlexW3023776937

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.