ArticleHeart (British Cardiac Society)2020
Acute myocardial injury is common in patients with COVID-19 and impairs their prognosis.
Article in Heart (British Cardiac Society), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed, 11 syntheses or guidelines pooled it, 202 citations in OpenAlex.
- Identifying patterns of reported findings on long-term cardiac complications of COVID-19: a systematic review and meta-analysis.BMC medicine · 2023Pooled it
- Prevalence of Cardiovascular Complications in Coronavirus Disease 2019 adult Patients: A Systematic Review and Meta-Analysis.Iranian journal of medical sciences · 2023Pooled it
- Systemic Inflammation May Induce Cardiac Injury in COVID-19 Patients Including Children and Adolescents Without Underlying Cardiovascular Diseases: A Systematic Review.Cardiovascular revascularization medicine : including molecular interventions · 2022Pooled it
- Cardiovascular diseases burden in COVID-19: Systematic review and meta-analysis.The American journal of emergency medicine · 2021Pooled it
- Prevalence and impact of cardiac injury on COVID-19: A systematic review and meta-analysis.Clinical cardiology · 2021Pooled it
- Demographic risk factors for COVID-19 infection, severity, ICU admission and death: a meta-analysis of 59 studies.BMJ open · 2021Pooled it
- Prevalence and clinical outcomes of cardiac injury in patients with COVID-19: A systematic review and meta-analysis.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2021Pooled it
- The potential association between common comorbidities and severity and mortality of coronavirus disease 2019: A pooled analysis.Clinical cardiology · 2020Pooled it
- Association of cardiac biomarkers and comorbidities with increased mortality, severity, and cardiac injury in COVID-19 patients: A meta-regression and decision tree analysis.Journal of medical virology · 2020Pooled it
- Clinical characteristics of COVID-19 with cardiac injury: a systematic review and meta-analysis.Epidemiology and infection · 2020Pooled it
- Factors associated with disease severity and mortality among patients with COVID-19: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Elevated plasma sTIM-3 levels in patients with severe COVID-19.The Journal of allergy and clinical immunology · 2021Trial
- Acute Myocardial Infarction during the COVID-19 Pandemic: Long-Term Outcomes and Prognosis-A Systematic Review.Life (Basel, Switzerland) · 2024Review
- Atypical Complications during the Course of COVID-19: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2024Review
- Identification of genetic loci jointly influencing COVID-19 and coronary heart diseases.Human genomics · 2023Article
- Artificial intelligence-enhanced electrocardiography for early assessment of coronavirus disease 2019 severity.Scientific reports · 2023Article
- COVID-19 and Acute Cardiac Injury: Clinical Manifestations, Biomarkers, Mechanisms, Diagnosis, and Treatment.Current cardiology reports · 2023Review
- Association Between COVID-19 Infection and Cardiac Biomarkers in Hospitalized Patients at a Tertiary Care Center.Cureus · 2023Article
- The Role of Multidisciplinary Approaches in the Treatment of Patients with Heart Failure and Coagulopathy of COVID-19.Journal of cardiovascular development and disease · 2023Review
- Interaction of COVID-19 With Common Cardiovascular Disorders.Circulation research · 2023Review
58 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
26 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe sought to explore the prevalence and immediate clinical implications of acute myocardial injury in a cohort of patients with COVID-19 in a region of China where medical resources are less stressed than in Wuhan (the epicentre of the pandemic).
methodsWe prospectively assessed the medical records, laboratory results, chest CT images and use of medication in a cohort of patients presenting to two designated covid-19 treatment centres in Sichuan, China. Outcomes of interest included death, admission to an intensive care unit (ICU), need for mechanical ventilation, treatment with vasoactive agents and classification of disease severity. Acute myocardial injury was defined by a value of high-sensitivity troponin T (hs-TnT) greater than the normal upper limit.
resultsA total of 101 cases were enrolled from January to 10 March 2020 (average age 49 years, IQR 34-62 years). Acute myocardial injury was present in 15.8% of patients, nearly half of whom had a hs-TnT value fivefold greater than the normal upper limit. Patients with acute myocardial injury were older, with a higher prevalence of pre-existing cardiovascular disease and more likely to require ICU admission (62.5% vs 24.7%, p=0.003), mechanical ventilation (43.5% vs 4.7%, p<0.001) and treatment with vasoactive agents (31.2% vs 0%, p<0.001). Log hs-TnT was associated with disease severity (OR 6.63, 95% CI 2.24 to 19.65), and all of the three deaths occurred in patients with acute myocardial injury.
conclusionAcute myocardial injury is common in patients with COVID-19 and is associated with adverse prognosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.