ArticleeNeuro
An Intersectional Viral-Genetic Method for Fluorescent Tracing of Axon Collaterals Reveals Details of Noradrenergic Locus Coeruleus Structure.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- Brain-wide arousal signals are segregated from movement planning in the superior colliculus of the macaque.eLife · 2026Article
- Inferring norepinephrine dynamics from partial observations reveals the temporal structure of elevations during arousal.bioRxiv : the preprint server for biology · 2026Article
- Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states.Neuron · 2026Article
- Inverse Association of Locus Coeruleus MRI Integrity With Structural Volume and Its Impact on Individual's Inattentiveness.Human brain mapping · 2025Article
- Prefrontal Cortex subregions provide distinct visual and behavioral feedback modulation to the Primary Visual Cortex.bioRxiv : the preprint server for biology · 2025Article
- Article
- The locus coeruleus influences behavior by coordinating effective integration of fear memories and sensory input.PLoS biology · 2025Article
- Mechanisms of neuromodulatory volume transmission.Molecular psychiatry · 2024Review
- Sex differences in single neuron function and proteomics profiles examined by patch-clamp and mass spectrometry in the locus coeruleus of the adult mouse.Acta physiologica (Oxford, England) · 2024Article
- Shining light on the noradrenergic system.Neurophotonics · 2023Review
- Cognitive Test Solution in Mice with Different Brain Weights after Atomoxetine.Neurology international · 2023Article
- Sleep disturbances in autism spectrum disorder: Animal models, neural mechanisms, and therapeutics.Neurobiology of sleep and circadian rhythms · 2023Review
- Article
- Properties and modulation of excitatory inputs to the locus coeruleus.The Journal of physiology · 2022Article
- Natural locus coeruleus dynamics during feeding.Science advances · 2022Article
- Delta Opioid Receptors and Enkephalinergic Signaling within Locus Coeruleus Promote Stress Resilience.Brain sciences · 2022Article
- A CRISPR toolbox for generating intersectional genetic mouse models for functional, molecular, and anatomical circuit mapping.BMC biology · 2022Article
- Probing the structure and function of locus coeruleus projections to CNS motor centers.Frontiers in neural circuits · 2022Article
- Locus Coeruleus Norepinephrine in Learned Behavior: Anatomical Modularity and Spatiotemporal Integration in Targets.Frontiers in neural circuits · 2021Review
- Extrinsic neuromodulation in the rodent olfactory bulb.Cell and tissue research · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Understanding the function of broadly projecting neurons depends on comprehensive knowledge of the distribution and targets of their axon collaterals. While retrograde tracers and, more recently, retrograde viral vectors have been used to identify efferent projections, they have limited ability to reveal the full pattern of axon collaterals from complex, heterogeneous neuronal populations. Here we describe TrAC (tracing axon collaterals), an intersectional recombinase-based viral-genetic strategy that allows simultaneous visualization of axons from a genetically defined neuronal population and a projection-based subpopulation. To test this new method, we have applied TrAC to analysis of locus coeruleus norepinephrine (LC-NE)-containing neurons projecting to medial prefrontal cortex (mPFC) and primary motor cortex (M1) in laboratory mice. TrAC allowed us to label each projection-based LC-NE subpopulation, together with all remaining LC-NE neurons, in isolation from other noradrenergic populations. This analysis revealed mPFC-projecting and M1-projecting LC-NE subpopulations differ from each other and from the LC as a whole in their patterns of axon collateralization. Thus, TrAC complements and extends existing axon tracing methods by permitting analyses that have not previously been possible with complex genetically defined neuronal populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.