Evidence map›Paper›PMID 32354741›Full record

ArticleThe Journal of biological chemistry2020

Estrogen receptor α (ERα)-binding super-enhancers drive key mediators that control uterine estrogen responses in mice.

Sylvia C Hewitt, Sara A Grimm, San-Pin Wu, Francesco J DeMayo, Kenneth S Korach

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  5. Phospholipases: Paving the Way for a New Life.Reproductive sciences (Thousand Oaks, Calif.) · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Genomic analysis of the rhesus macaque (Ecology and evolution · 2023
    Article
  11. Article
  12. Chromatin architectural factor CTCF is essential for progesterone-dependent uterine maturation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sylvia C HewittReproductive and Developmental Biology Laboratory, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina, USA Sylvia.Hewitt@nih.gov.ORCID 0000-0001-7713-0805
Sara A GrimmIntegrative Bioinformatics Support Group, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina, USA.
San-Pin WuReproductive and Developmental Biology Laboratory, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina, USA.
Francesco J DeMayoReproductive and Developmental Biology Laboratory, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina, USA.
Kenneth S KorachReproductive and Developmental Biology Laboratory, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina, USA.
National Institutes of Health · US

Funding

Gene Expression and MicroarraysZICES102445 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI GERRISH, KEVIN · 2009 to 2025
$31.6M
Environmental Signaling in Reproduction and PregnancyZIAES103311 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DEMAYO, FRANCESCO · 2016 to 2025
$30.5M
Chemical Receptor Interactions In Reproduction And Hormonal ToxicityZIAES070065 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI KORACH, KENNETH S · 2009 to 2019
$29.6M
Intramural NIH HHS ZIA ES070065Intramural NIH HHS ZIA ES103311
6 · The paper itself

Abstract

Estrogen receptor α (ERα) modulates gene expression by interacting with chromatin regions that are frequently distal from the promoters of estrogen-regulated genes. Active chromatin-enriched "super-enhancer" (SE) regions, mainly observed in

Indexed as

AnimalsBinding SitesChromatinEstradiolEstrogen Receptor alphaFemaleHistonesHomeodomain ProteinsLeukemia Inhibitory FactorMiceMice, Inbred C57BLMice, KnockoutProtein BindingRetinoic Acid Receptor alphaSignal TransductionTransforming Growth Factor betaChromatinEstradiolEstrogen Receptor alphaHistonesHomeodomain ProteinsLeukemia Inhibitory FactorLif protein, mouseRetinoic Acid Receptor alphaTransforming Growth Factor betachromatin conformation capturechromatin loopingchromatin modificationepigenetic regulationestrogen receptorfemale reproductiongene expressionreproductionsuper-enhancertranscription

Identifiers

PMID32354741
PMCPMC7307205
OpenAlexW3021367274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.