ArticleAJNR. American journal of neuroradiology2020
Direct In Vivo MRI Discrimination of Brain Stem Nuclei and Pathways.
Article in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Evaluating the quality of brainstem ROI registration using structural and diffusion MRI.Frontiers in neuroscience · 2026Article
- Stitching brain and spinal cord DTI using cross-correlation registration: toward an atlas of spinal tracts.European radiology experimental · 2025Article
- Atlas-guided brain projection tracts: From regions of interest to tractography 3D rendering.Journal of anatomy · 2025Article
- Redefining the phenotype of alpha-methylacyl-CoA racemase (AMACR) deficiency.Orphanet journal of rare diseases · 2024Article
- Visualization of small brain nuclei with a high-spatial resolution, clinically available whole-body PET scanner.Annals of nuclear medicine · 2024Article
- Brainstem anatomy with 7-T MRI: in vivo assessment and ex vivo comparison.European radiology experimental · 2023Article
- Automatic planning of MR-guided transcranial focused ultrasound treatment for essential tremor.Frontiers in neuroimaging · 2023Article
- The brainstem in multiple sclerosis: MR identification of tracts and nuclei damage.Insights into imaging · 2021Article
- Longitudinal Assessment of Neuroradiologic Features in Wolfram Syndrome.AJNR. American journal of neuroradiology · 2020Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
background and purposeThe brain stem is a complex configuration of small nuclei and pathways for motor, sensory, and autonomic control that are essential for life, yet internal brain stem anatomy is difficult to characterize in living subjects. We hypothesized that the 3D fast gray matter acquisition T1 inversion recovery sequence, which uses a short inversion time to suppress signal from white matter, could improve contrast resolution of brain stem pathways and nuclei with 3T MR imaging. MATERIALS AND
methodsAfter preliminary optimization for contrast resolution, the fast gray matter acquisition T1 inversion recovery sequence was performed in 10 healthy subjects (5 women; mean age, 28.8 ± 4.8 years) with the following parameters: TR/TE/TI = 3000/2.55/410 ms, flip angle = 4°, isotropic resolution = 0.8 mm, with 4 averages (acquired separately and averaged outside
resultsThe fast gray matter acquisition T1 inversion recovery sequence generated excellent contrast resolution of small brain stem pathways in all 3 planes for all 10 subjects. Several nuclei could be resolved directly by image contrast alone or indirectly located due to bordering visualized structures (eg, locus coeruleus and pedunculopontine nucleus).
conclusionsThe fast gray matter acquisition T1 inversion recovery sequence has the potential to provide imaging correlates to clinical conditions that affect the brain stem, improve neurosurgical navigation, validate diffusion tractography of the brain stem, and generate a 3D atlas for automatic parcellation of specific brain stem structures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.