ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2020
Examining Specificity of Neural Correlates of Childhood Psychotic-like Experiences During an Emotional n-Back Task.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Differential adolescent neurodevelopment of emotion processing across internalizing psychopathology and childhood adversity.Developmental cognitive neuroscience · 2026Article
- The longitudinal structure of cognition in the ABCD study and associations with neural function and psychopathology: A Bayesian probabilistic principal components analysis.Developmental cognitive neuroscience · 2026Article
- Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in Children.Biological psychiatry global open science · 2025Article
- Negative life events during early adolescence are associated with neural deactivation to emotional stimuli.Brain and cognition · 2025Article
- Manifold Learning Uncovers Nonlinear Interactions Between the Adolescent Brain and Environment That Predict Emotional and Behavioral Problems.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Neural and Behavioral Correlates of Binge Eating in 9- to 10-Year-Old Children.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Observational
- Exploring the n-back task: insights, applications, and future directions.Frontiers in human neuroscience · 2025Review
- Article
- Working memory performance is related to childhood trauma but not psychotic-like experiences in a nonpsychiatric sample.Psychological trauma : theory, research, practice and policy · 2024Article
- Unique versus shared neural correlates of externalizing psychopathology in late childhood.Journal of psychopathology and clinical science · 2024Article
- Manifold learning uncovers nonlinear interactions between the adolescent brain and environment that predict emotional and behavioral problems.bioRxiv : the preprint server for biology · 2024Article
- Genetic variation in endocannabinoid signaling: Anxiety, depression, and threat- and reward-related brain functioning during the transition into adolescence.Behavioural brain research · 2024Article
- Understanding psychotic-like experiences in children in the context of dimensions of psychological problems.Frontiers in child and adolescent psychiatry · 2024Article
- Perceiving visual negative stimuli in schizophrenia and bipolar disorder: Meta-analytic evidence of a common altered thalamic-parahippocampal-basal ganglia circuit.Neuroimage. Reports · 2023Article
- Cognitive Dysfunction as a Risk Factor for Psychosis.Current topics in behavioral neurosciences · 2023Article
- Associations between social behaviors and experiences with neural correlates of implicit emotion regulation in middle childhood.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
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4 authors.
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Abstract
backgroundPsychotic-like experiences (PLEs) during childhood are associated with greater risk of developing a psychotic disorder in adulthood, highlighting the importance of identifying neural correlates of childhood PLEs. Furthermore, impairment of cognitive functions, such as working memory and emotion regulation, has also been linked to psychosis risk as well as to disruptions in several brain regions. However, impairments in these domains have also been linked to other disorders, including depression. Therefore, the aim of the current study was to examine whether neural impairments in regions associated with working memory and implicit emotion regulation impairments are specific to PLEs versus depression.
methodsThe current study used an emotional n-back task to examine the relationship between childhood PLEs and neural activation of regions involved in both working memory and implicit emotion regulation using data from 8805 9- to 11-year-olds in the Adolescent Brain Cognitive Development (ABCD) Study 2.0 release. To examine specificity, we also analyzed associations with depressive symptoms.
resultsOur results indicated that increased PLEs during middle childhood were associated with decreased activation of the dorsolateral prefrontal cortex, striatum, and pallidum during trials requiring working memory. In contrast, increased activation of the parahippocampus, caudate, nucleus accumbens, and rostral anterior cingulate during face-viewing trials was associated with increased depressive symptoms.
conclusionsThese results support the dimensional view of psychosis across the lifespan, providing evidence that neural correlates of PLEs, such as decreased activation during working memory, are present during middle childhood. Furthermore, these correlates are specific to psychotic-like symptoms as compared with depressive symptoms.
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