Evidence map›Paper›PMID 32354637›Full record

ArticleKidney international2020

COVID-19 infection in kidney transplant recipients.

Debasish Banerjee, Joyce Popoola, Sapna Shah, Irina Chis Ster, Virginia Quan, Mysore Phanish

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 215 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
215citing papers in PubMed, 14 pooled it
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

215 citing papers in PubMed, 14 syntheses or guidelines pooled it, 375 citations in OpenAlex.

  1. Incidence and Outcomes of COVID-19 in People With CKD: A Systematic Review and Meta-analysis.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021
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  3. Effect of immunosuppression maintenance in solid organ transplant recipients with COVID-19: Systematic review and meta-analysis.Transplant infectious disease : an official journal of the Transplantation Society · 2021
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  11. COVID-19 clinical manifestations and treatment strategies among solid-organ recipients: A systematic review of cases.Transplant infectious disease : an official journal of the Transplantation Society · 2020
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155 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Debasish BanerjeeRenal and Transplantation Unit, St. George's University Hospital National Health Service Foundation Trust, London, UK; Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, UK. Electronic address: debasish.banerjee@stgeorges.nhs.uk.
Joyce PopoolaRenal and Transplantation Unit, St. George's University Hospital National Health Service Foundation Trust, London, UK; Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, UK.
Sapna ShahRenal Unit, King's College Hospital, London, UK.
Irina Chis SterInfection and Immunity Research Institute, St. George's, University of London, London, UK.
Virginia QuanRenal Unit, Epsom and St. Helier University Hospitals National Health Service Trust, London, UK.
Mysore PhanishRenal Unit, Epsom and St. Helier University Hospitals National Health Service Trust, London, UK; South West Thames Institute for Renal Research, St. Helier Hospital, London, UK.
St George's, University of London · GBEpsom and St Helier University Hospitals NHS Trust · GBKing's College Hospital · GBNational Health Service · GBSt Helier Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

By 21 March 2020 infections related to the novel coronavirus SARS-CoV-2 had affected people from 177 countries and caused 11,252 reported deaths worldwide. Little is known about risk, presentation and outcomes of SARS-CoV-2 (COVID-19) infection in kidney transplantation recipients, who may be at high-risk due to long-term immunosuppression, comorbidity and residual chronic kidney disease. Whilst COVID-19 is predominantly a respiratory disease, in severe cases it can cause kidney and multi-organ failure. It is unknown if immunocompromised hosts are at higher risk of more severe systemic disease. Therefore, we report on seven cases of COVID-19 in kidney transplant recipients (median age 54 (range 45-69), three females, from a cohort of 2082 managed transplant follow-up patients) over a six-week period in three south London hospitals. Two of seven patients presented within three months of transplantation. Overall, two were managed on an out-patient basis, but the remaining five required hospital admission, four in intensive care units. All patients displayed respiratory symptoms and fever. Other common clinical features included hypoxia, chest crepitation, lymphopenia and high C-reactive protein. Very high D dimer, ferritin and troponin levels occurred in severe cases and likely prognostic. Immunosuppression was modified in six of seven patients. Three patients with severe disease were diabetic. During a three week follow up one patient recovered, and one patient died. Thus, our findings suggest COVID-19 infection in kidney transplant patients may be severe, requiring intensive care admission. The symptoms are predominantly respiratory and associated with fever. Most patients had their immunosuppression reduced and were treated with supportive therapy.

Indexed as

AgedBetacoronavirusCoronavirus InfectionsCOVID-19FemaleFeverFollow-Up StudiesGraft RejectionHumansImmunocompromised HostImmunosuppression TherapyKidney TransplantationMaleMiddle AgedPandemicsPneumonia, ViralCOVID-19immunosuppressionkidney transplantationSARS-CoV-2 infection

Identifiers

PMID32354637
PMCPMC7142878
OpenAlexW3015434455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.