Evidence map›Paper›PMID 32354551›Full record

ReviewSeminars in thoracic and cardiovascular surgery. Pediatric cardiac surgery annual2020

Molecular Approaches in Single Ventricle Management.

Omar Toubat, S Ram Kumar

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in thoracic and cardiovascular surgery. Pediatric cardiac surgery annual, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Omar ToubatDivision of Cardiac Surgery, Department of Surgery, University of Southern California, Los Angeles, California.
S Ram KumarDivision of Cardiac Surgery, Department of Surgery, University of Southern California, Los Angeles, California; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California; Heart Institute, Children's Hospital, Los Angeles, Los Angeles, California. Electronic address: rsubramanyan@surgery.usc.edu.
University of Southern California · US

Funding

Role of delta-like ligand-4 signaling in cardiac outflow tract developmentK08HL121191 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SUBRAMANYAN, RAM KUMAR · 2016 to 2020
$843k
Prox1 and COUP-TFII interactions regulate lymphatic endothelial cell differentiationF30HL154324 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOUBAT, OMAR · 2020 to 2022
$115k
NHLBI NIH HHS F30 HL154324NHLBI NIH HHS K08 HL121191
6 · The paper itself

Abstract

Advances in medical and surgical management have significantly improved early outcomes in single ventricle congenital heart disease over the last 2 decades. Despite these advances, long-term outcomes remain suboptimal and therapeutic options to address systemic ventricular and/or Fontan failure are limited even in the modern era. Intricate molecular biologic techniques have shed light into the mechanisms of development of single ventricle disease. Efforts are underway to leverage this knowledge to improve clinical diagnosis, therapy, and prognostication. Cell-based therapies aimed at inducing cardiomyocyte proliferation and preventing delayed cardiac dysfunction have already entered the clinical realm. Several more novel biological therapies are expected to become available for patients with single ventricle disease in the near future. These scientific advancements provide us hope and reaffirm our faith that molecular medicine will usher in the next generation of therapies for single ventricle management.

Indexed as

Biological TherapyCell- and Tissue-Based TherapyFontan ProcedureHeart Defects, CongenitalHeart VentriclesHumansCongenital heart diseaseMolecular medicineSingle ventricle

Identifiers

PMID32354551
PMCPMC9232387
OpenAlexW3018230543

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.