Evidence map›Paper›PMID 32354451›Full record

ArticleHeart rhythm2020

Eligibility for subcutaneous implantable cardioverter-defibrillator in congenital heart disease.

Linda Wang, Neeraj Javadekar, Ananya Rajagopalan, Nichole M Rogovoy, Kazi T Haq, Craig S Broberg, Larisa G Tereshchenko

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Heart rhythm, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03209726 (Assessment of Subcutaneous Implantable Cardioverter Defibrillator Eligibility With 12-lead Electrocardiogram), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03209726 completednot on this map

Assessment of Subcutaneous Implantable Cardioverter Defibrillator Eligibility With 12-lead Electrocardiogram

TypeobservationalSponsorLarisa TereshchenkoRan2017 to 2020Enrolled106ConditionsImplantable Defibrillator User
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Article
  6. Deep learning-based insights on T:R ratio behaviour during prolonged screening for S-ICD eligibility.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Article
  7. Medical Therapy for Heart Failure in Adult Congenital Heart Disease Patients.Structural heart : the journal of the Heart Team · 2024
    Review
  8. Article
  9. Review
  10. Review
  11. S-ICD Implantation "Tips and Tricks".Reviews in cardiovascular medicine · 2023
    Review
  12. Review
  13. Digitizing ECG image: A new method and open-source software code.Computer methods and programs in biomedicine · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Linda WangOregon Health & Science University, Knight Cardiovascular Institute, Portland, Oregon.
Neeraj JavadekarOregon Health & Science University, Knight Cardiovascular Institute, Portland, Oregon.
Ananya RajagopalanOregon Health & Science University, Knight Cardiovascular Institute, Portland, Oregon.
Nichole M RogovoyOregon Health & Science University, Knight Cardiovascular Institute, Portland, Oregon.
Kazi T HaqOregon Health & Science University, Knight Cardiovascular Institute, Portland, Oregon.
Craig S BrobergOregon Health & Science University, Knight Cardiovascular Institute, Portland, Oregon.
Larisa G TereshchenkoOregon Health & Science University, Knight Cardiovascular Institute, Portland, Oregon. Electronic address: tereshch@ohsu.edu.
Oregon Health & Science University · US

Funding

Novel ECG Measures and Risk of Sudden Cardiac DeathR01HL118277 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TERESHCHENKO, LARISA GENNADIEVNA · 2013 to 2016
$1.5M
Novel ECG measures and risk of sudden cardiac deathR56HL118277 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TERESHCHENKO, LARISA GENNADIEVNA · 2018 to 2018
$396k
NHLBI NIH HHS R01 HL118277NHLBI NIH HHS R56 HL118277
6 · The paper itself

Abstract

backgroundAdult congenital heart disease (ACHD) patients can benefit from a subcutaneous implantable cardioverter-defibrillator (S-ICD).

objectiveThe purpose of this study was to assess left- and right-sided S-ICD eligibility in ACHD patients, use machine learning to predict S-ICD eligibility in ACHD patients, and transform 12-lead electrocardiogram (ECG) to S-ICD 3-lead ECG, and vice versa.

methodsACHD outpatients (n = 101; age 42 ± 14 years; 52% female; 85% white; left ventricular ejection fraction [LVEF] 56% ± 9%) were enrolled in a prospective study. Supine and standing 12-lead ECG were recorded simultaneously with a right- and left-sided S-ICD 3-lead ECG. Peak-to-peak QRS and T amplitudes; RR, PR, QT, QTc, and QRS intervals; Tmax, and R/Tmax (31 predictor variables) were tested. Model selection, training, and testing were performed using supine ECG datasets. Validation was performed using standing ECG datasets and an out-of-sample non-ACHD population (n = 68; age 54 ± 16 years; 54% female; 94% white; LVEF 61% ± 8%).

resultsForty percent of participants were ineligible for S-ICD. Tetralogy of Fallot patients passed right-sided screening (57%) more often than left-sided screening (21%; McNemar χ

conclusionNearly half of the contemporary ACHD population is ineligible for S-ICD. The odds of S-ICD eligibility are greater for female than for male ACHD patients. Machine learning prediction of S-ICD eligibility can be used for screening of S-ICD candidates.

Indexed as

Defibrillators, ImplantableAdultCross-Sectional StudiesDeath, Sudden, CardiacElectrocardiographyEligibility DeterminationFemaleHeart Defects, CongenitalHumansMalePatient SelectionProspective StudiesRisk FactorsROC CurveVentricular Function, LeftAdult congenital heart diseaseElectrocardiogramEligibilityMachine learningSubcutaneous implantable cardioverter-defibrillator

Identifiers

PMID32354451
PMCPMC7197388
OpenAlexW3019348515

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.