Evidence map›Paper›PMID 32354332›Full record

Observational studyRespiratory research2020

Heme metabolism genes Downregulated in COPD Cachexia.

Ava C Wilson, Preeti L Kumar, Sool Lee, Margaret M Parker, Itika Arora, Jarrett D Morrow, Emiel F M Wouters, Richard Casaburi, Stephen I Rennard, David A Lomas and 12 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 3 countries.

Ava C WilsonDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Preeti L KumarDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Sool LeeChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Margaret M ParkerChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Itika AroraDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jarrett D MorrowChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Emiel F M WoutersCentre of expertise for chronic organ failure, Horn, the Netherlands.
Richard CasaburiRehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor Harbor-UCLA Medical Center, Torrance, CA, USA.
Stephen I RennardDepartment of Medicine, Nebraska Medical Center, Omaha, NE, USA.
David A LomasUCL Respiratory, Division of Medicine, University College London, London, UK.
Alvar AgustiFundació Investigació Sanitària Illes Balears (FISIB), Ciber Enfermedades Respiratorias (CIBERES), Barcelona, Catalunya, Spain.
Ruth Tal-SingerGSK R&D, Collegeville, PA, USA.
Mark T DransfieldDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
J Michael WellsDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Surya P BhattDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
George WashkoDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Victor J ThannickalDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Hemant K TiwariDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Craig P HershChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Peter J CastaldiChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Edwin K SilvermanChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Merry-Lynn N McDonaldDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA. mmcdonald@uab.edu.
University of Alabama at Birmingham · USBrigham and Women's Hospital · USConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESGlaxoSmithKline (United States) · USHarbor–UCLA Medical Center · USNebraska Medical Center · USUniversity College London · GB

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Therapeutic Targeting of the Myofibroblast in Fibrotic Lung DiseaseP01HL114470 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI THANNICKAL, VICTOR J. · 2013 to 2022
$17.8M
SYSTEMS GENOMICS OF THE ASTHMA-COPD OVERLAP SYNDROMER01HL130512 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HERSH, CRAIG P · 2016 to 2019
$3.5M
INTEGRATIVE GENOMICS OF CLINICAL SUBTYPES IN COPDGENER01HL125583 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HERSH, CRAIG P · 2015 to 2018
$3.5M
Matrikines and COPD-PHR01HL148215 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WELLS, JAMES MICHAEL · 2019 to 2023
$2.4M
Integrative omics pipeline to identify novel COPD genes and pathwaysK25HL136846 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MORROW, JARRETT · 2017 to 2021
$945k
Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of Chronic Obstructive Pulmonary DiseaseK23HL133438 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BHATT, SURYA P. · 2016 to 2020
$921k
Network Medicine Approaches to Cachexia in COPDR00HL121087 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MCDONALD DONNELLY, MERRY-LYNN NOELLE · 2017 to 2019
$747k
The Role of PGP in COPD-associated Pulmonary HypertensionK08HL123940 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WELLS, JAMES MICHAEL · 2014 to 2018
$744k
NHLBI NIH HHS K08 HL123940NHLBI NIH HHS K23 HL133438NHLBI NIH HHS P01 HL114470NHLBI NIH HHS R00 HL121087NHLBI NIH HHS R01 HL148215NHLBI NIH HHS U01 HL089897NIH HHS R00HL121087NIH HHS R01HL125583NIH HHS R01HL130512NIH HHS U01 HL089856NIH HHS U01 HL089897
6 · The paper itself

Abstract

introductionCachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes. Our goal was to identify differential gene expression signatures associated with COPD cachexia in current and former smokers.

methodsWe analyzed whole-blood gene expression data from participants with COPD in a discovery cohort (COPDGene, N = 400) and assessed replication (ECLIPSE, N = 114). To approximate the consensus definition using available criteria, cachexia was defined as weight-loss > 5% in the past 12 months or low body mass index (BMI) (< 20 kg/m

resultsThe prevalence of COPD cachexia was 13.7% in COPDGene and 7.9% in ECLIPSE. Fourteen genes were differentially downregulated in cachectic versus non-cachectic COPD patients in COPDGene (FDR < 0.05) and ECLIPSE (FDR < 0.05). DISCUSSION: Several replicated genes regulating heme metabolism were downregulated among participants with COPD cachexia. Impaired heme biosynthesis may contribute to cachexia development through free-iron buildup and oxidative tissue damage.

Indexed as

AgedAged, 80 and overCachexiaCohort StudiesDown-RegulationFemaleFollow-Up StudiesGenome-Wide Association StudyHemeHumansLongitudinal StudiesMaleMiddle AgedPulmonary Disease, Chronic ObstructiveHemeChronic obstructive pulmonary disease

Identifiers

PMID32354332
PMCPMC7193359
OpenAlexW3021063734

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.