Evidence map›Paper›PMID 32354171›Full record

ArticleCells2020

Genome Editing of the

Aleksandra Ulman, Klaudia Skrzypek, Paweł Konieczny, Claudio Mussolino, Toni Cathomen, Marcin Majka

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Aleksandra UlmanDepartment of Transplantation, Faculty of Medicine, Institute of Pediatrics, Jagiellonian University Medical College, 30-663 Cracow, Poland.
Klaudia SkrzypekDepartment of Transplantation, Faculty of Medicine, Institute of Pediatrics, Jagiellonian University Medical College, 30-663 Cracow, Poland.ORCID 0000-0002-3997-924X
Paweł KoniecznyDepartment of Transplantation, Faculty of Medicine, Institute of Pediatrics, Jagiellonian University Medical College, 30-663 Cracow, Poland.
Claudio MussolinoInstitute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, 79106 Freiburg, Germany.
Toni CathomenInstitute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, 79106 Freiburg, Germany.ORCID 0000-0002-7757-4630
Marcin MajkaDepartment of Transplantation, Faculty of Medicine, Institute of Pediatrics, Jagiellonian University Medical College, 30-663 Cracow, Poland.ORCID 0000-0002-0429-681X
Jagiellonian University · PLUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome editing (GE) tools and RNA interference technology enable the modulation of gene expression in cancer research. While GE mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 or transcription activator-like effector nucleases (TALEN) activity can be used to induce gene knockouts, shRNA interacts with the targeted transcript, resulting in gene knockdown. Here, we compare three different methods for

Indexed as

Base SequenceCell Line, TumorCRISPR-Cas SystemsGene EditingGene ExpressionHEK293 CellsHistone Deacetylase 1HumansRhabdomyosarcomaSnail Family Transcription FactorsTranscription Activator-Like Effector NucleasesHistone Deacetylase 1SNAI1 protein, humanSnail Family Transcription FactorsTranscription Activator-Like Effector NucleasesCRISPR/Cas9designer nucleasesgenome editingrhabdomyosarcoma (RMS)shRNASNAI1 (SNAIL) transcription factorTALEN

Identifiers

PMID32354171
PMCPMC7290443
OpenAlexW3023291396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.