Evidence map›Paper›PMID 32354065›Full record

ArticleGenes2020

Monika Linek, Maren Doelle, Tosso Leeb, Anina Bauer, Fabienne Leuthard, Jan Henkel, Danika Bannasch, Vidhya Jagannathan, Monika M Welle

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Monika LinekAniCura Tierärztliche Spezialisten, 22043 Hamburg, Germany.
Maren DoelleAniCura Tierärztliche Spezialisten, 22043 Hamburg, Germany.
Tosso LeebInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.ORCID 0000-0003-0553-4880
Anina BauerInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.
Fabienne LeuthardInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.
Jan HenkelInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.
Danika BannaschInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.ORCID 0000-0002-7614-7207
Vidhya JagannathanInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.ORCID 0000-0002-8155-0041
Monika M WelleDermfocus, University of Bern, 3001 Bern, Switzerland.
University of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 4-month-old female Irish Terrier presented with a well demarcated ulcerative and crusting lesion in the right ear canal. Histological analysis revealed epidermal hyperplasia with severe acantholysis affecting all suprabasal layers of the epidermis, which prompted a presumptive diagnosis of canine Darier disease. The lesion was successfully treated by repeated laser ablation of the affected epidermis. Over the course of three years, the dog additionally developed three dermal nodules of up to 4 cm in diameter that were excised and healed without complications. Histology of the excised tissue revealed multiple infundibular cysts extending from the upper dermis to the subcutis. The cysts were lined by squamous epithelium, which presented with abundant acantholysis of suprabasal keratinocytes. Infundibular cysts represent a novel finding not previously reported in Darier patients. Whole genome sequencing of the affected dog was performed, and the functional candidate genes for Darier disease (

Indexed as

AcantholysisAnimalsCalcium-Transporting ATPasesDarier DiseaseDog DiseasesDogsEar CanalEpidermisFemaleHaploinsufficiencyHeterozygoteHumansKeratinocytesPemphigus, Benign FamilialSarcoplasmic Reticulum Calcium-Transporting ATPasesSkinATP2A2 protein, humanATP2C1 protein, humanCalcium-Transporting ATPasesSarcoplasmic Reticulum Calcium-Transporting ATPasesacantholysisanimal modelcalciumCanis lupus familiarisdermatologydesmosomedogprecision medicineskinveterinary medicine

Identifiers

PMID32354065
PMCPMC7291265
OpenAlexW3023424407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.