Comparison of Substituting Ability of Nitronate versus Enolate for Direct Substitution of a Nitro Group.

Yusuke Mukaijo, Soichi Yokoyama, Nagatoshi Nishiwaki

Abstract readComparative Study

In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Unusual Reactivities ofMolecules (Basel, Switzerland) · 2022
Article
A Walk through Recent Nitro Chemistry Advances.Molecules (Basel, Switzerland) · 2020
Article
The Cyclic Nitronate Route to Pharmaceutical Molecules: Synthesis of GSK's Potent PDE4 Inhibitor as a Case Study.Molecules (Basel, Switzerland) · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yusuke MukaijoSchool of Environmental Science and Engineering, Kochi University of Technology, Tosayamada, Kami, Kochi 782-8502, Japan.

Soichi YokoyamaSchool of Environmental Science and Engineering, Kochi University of Technology, Tosayamada, Kami, Kochi 782-8502, Japan.

Nagatoshi NishiwakiSchool of Environmental Science and Engineering, Kochi University of Technology, Tosayamada, Kami, Kochi 782-8502, Japan.ORCID 0000-0002-6052-8697

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

α-Nitrocinnamate underwent the conjugate addition of an active methylene compound such as nitroacetate, 1,3-dicarbonyl compound, or α-nitroketone, and the following ring closure afforded functionalized heterocyclic frameworks. The reaction of cinnamate with nitroacetate occurs via nucleophilic substitution of a nitro group by the

Indexed as

CarbonCarboxylic AcidsElectronsEstersFuransIonsIsoxazolesKetonesMagnetic Resonance SpectroscopyNitro CompoundsNitrogen OxidesOxidesPropylaminesStereoisomerism2,3-dihydrofuranCarbonCarboxylic AcidsEstersFuransIonsIsoxazolesKetonesNitro CompoundsNitrogen OxidesnitronesOxidesPropylamines1,3-dicarbonyl compoundconjugate additiondihydrofuranenolateisoxazoline N-oxidenitro groupnitroketonenitronatenucleophilic substitution

Identifiers

PMID32353998

DOI10.3390/molecules25092048

PMCPMC7248694

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.