Evidence map›Paper›PMID 32353989›Full record

ArticleMolecules (Basel, Switzerland)2020

Imperatorin as a Promising Chemotherapeutic Agent Against Human Larynx Cancer and Rhabdomyosarcoma Cells.

Aneta Grabarska, Krystyna Skalicka-Woźniak, Michał Kiełbus, Magdalena Dmoszyńska-Graniczka, Paulina Miziak, Justyna Szumiło, Ewa Nowosadzka, Krystyna Kowalczuk, Sherief Khalifa, Jolanta Smok-Kalwat and 5 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Effects ofFood science & nutrition · 2025
    Article
  3. Article
  4. Quantitative Analysis of Isopimpinellin fromMolecules (Basel, Switzerland) · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Isoquinoline Alkaloids fromInternational journal of molecular sciences · 2022
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Direct Targeting of CREB1 with Imperatorin Inhibits TGFAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Aneta GrabarskaDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-3823-1467
Krystyna Skalicka-WoźniakIndependent Laboratory of Natural Products Chemistry, Medical University of Lublin, 20-093 Lublin, Poland.
Michał KiełbusDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.
Magdalena Dmoszyńska-GraniczkaDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.
Paulina MiziakDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.
Justyna SzumiłoDepartment of Clinical Pathomorphology, Medical University of Lublin, 20-093 Lublin, Poland.
Ewa NowosadzkaDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.
Krystyna KowalczukDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.
Sherief KhalifaCollege of Pharmacy, Gulf Medical University, P.O. Box 4184, Ajman, UAE.
Jolanta Smok-KalwatDepartment of Clinical Oncology, Holy Cross Cancer Center, 25-734 Kielce, Poland.
Janusz KlatkaDepartment of Otolaryngology and Laryngological Oncology, Medical University of Lublin, 20-954 Lublin, Poland.
Krzysztof KupiszDepartment of Otolaryngology and Laryngological Oncology, Medical University of Lublin, 20-954 Lublin, Poland.
Krzysztof PolbergDepartment of Otolaryngology, MSWiA Hospital, 20-331 Lublin, Poland.
Adolfo Rivero-MüllerDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-9794-802X
Andrzej StepulakDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-1872-394X
Medical University of Lublin · PL1 Military Clinical Hospital with Outpatient Clinic · PLGulf Medical University · AEHoly Cross University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Naturally occurring coumarins are bioactive compounds widely used in Asian traditional medicine. They have been shown to inhibit proliferation, induce apoptosis, and/or enhance the cytotoxicity of currently used drugs against a variety of cancer cell types. The aim of our study was to examine the antiproliferative activity of different linear furanocoumarins on human rhabdomyosarcoma, lung, and larynx cancer cell lines, and dissolve their cellular mechanism of action. The coumarins were isolated from fruits of

Indexed as

Angelica archangelicaAntineoplastic Agents, PhytogenicApoptosisCell CycleCell Line, TumorCell ProliferationCell SurvivalChromatographyCyclin-Dependent Kinase Inhibitor p21Drug Screening Assays, AntitumorFibroblastsFlow CytometryFruitFurocoumarinsHumansLaryngeal NeoplasmsAntineoplastic Agents, PhytogenicCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21FurocoumarinsimperatorinL-Lactate DehydrogenaseAngelica archangelicafuranocoumarinsimperatorinlarynx cancerPastinaca sativarhabdomyosarcoma

Identifiers

PMID32353989
PMCPMC7248852
OpenAlexW3022718721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.