ArticleInternational journal of molecular sciences2020
Degradation, Bone Regeneration and Tissue Response of an Innovative Volume Stable Magnesium-Supported GBR/GTR Barrier Membrane.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Resorbable scaffolds for alveolar ridge augmentation procedures: A systematic review.International journal of implant dentistry · 2026Pooled it
- Effect of Different Membranes on Vertical Bone Regeneration: A Systematic Review and Network Meta-Analysis.BioMed research international · 2022Pooled it
- Growth Factors in Oral Tissue Engineering: New Perspectives and Current Therapeutic Options.BioMed research international · 2021Pooled it
- Design and applications of barrier membranes for guided bone regeneration.Bioactive materials · 2026Review
- Materials advances in GTR membrane: A comprehensive review.Journal of Taibah University Medical Sciences · 2026Review
- Magnesium-Based Membrane for Alveolar Ridge Regeneration-A Scoping Review.Journal of functional biomaterials · 2026Review
- Controlled Magnesium Ion Delivery via Mg-Sputtered Nerve Conduit for Enhancing Peripheral Nerve Regeneration.Advanced healthcare materials · 2025Article
- Radiographic Evidence of Immature Bone Architecture After Sinus Grafting: A Multidimensional Image Analysis Approach.Diagnostics (Basel, Switzerland) · 2025Article
- Comparative evaluation of allograft particulate bone and cortical bone blocks combined with xenograft bone for labial bone defects in the aesthetic zone: a prospective cohort study.BMC oral health · 2025Article
- Research status and prospects of biodegradable magnesium-based metal guided bone regeneration membranes.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2024Review
- Osteogenic Potential of Magnesium Oxide Nanoparticles in Bone Regeneration: A Systematic Review.Cureus · 2024Review
- Collagen membrane functionalized with magnesium oxide via room-temperature atomic layer deposition promotes osteopromotive and antimicrobial properties.Bioactive materials · 2023Article
- Guided Bone Regeneration Using a Novel Magnesium Membrane: A Literature Review and a Report of Two Cases in Humans.Journal of functional biomaterials · 2023Review
- Degradable Pure Magnesium Used as a Barrier Film for Oral Bone Regeneration.Journal of functional biomaterials · 2022Article
- Recent advances in biofunctional guided bone regeneration materials for repairing defective alveolar and maxillofacial bone: A review.The Japanese dental science review · 2022Review
- Preparation of functional poly-(lactic acid-co-glycolic acid)-based guided bone-regeneration membrane and its application in the reconstruction of mandibular defects in rats.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022Article
- Applications of Biodegradable Magnesium-Based Materials in Reconstructive Oral and Maxillofacial Surgery: A Review.Molecules (Basel, Switzerland) · 2022Review
- Nanotopographical 3D-Printed Poly(ε-caprolactone) Scaffolds Enhance Proliferation and Osteogenic Differentiation of Urine-Derived Stem Cells for Bone Regeneration.Pharmaceutics · 2022Article
- Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review.Polymers · 2022Review
- Editorial of the Special Issue: "Soft and Hard Tissue Regeneration".Biomedicines · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
introductionBioresorbable collagenous barrier membranes are used to prevent premature soft tissue ingrowth and to allow bone regeneration. For volume stable indications, only non-absorbable synthetic materials are available. This study investigates a new bioresorbable hydrofluoric acid (HF)-treated magnesium (Mg) mesh in a native collagen membrane for volume stable situations. MATERIALS AND
methodsHF-treated and untreated Mg were compared in direct and indirect cytocompatibility assays. In vivo, 18 New Zealand White Rabbits received each four 8 mm calvarial defects and were divided into four groups: (a) HF-treated Mg mesh/collagen membrane, (b) untreated Mg mesh/collagen membrane (c) collagen membrane and (d) sham operation. After 6, 12 and 18 weeks, Mg degradation and bone regeneration was measured using radiological and histological methods.
resultsIn vitro, HF-treated Mg showed higher cytocompatibility. Histopathologically, HF-Mg prevented gas cavities and was degraded by mononuclear cells via phagocytosis up to 12 weeks. Untreated Mg showed partially significant more gas cavities and a fibrous tissue reaction. Bone regeneration was not significantly different between all groups. DISCUSSION AND
conclusionsHF-Mg meshes embedded in native collagen membranes represent a volume stable and biocompatible alternative to the non-absorbable synthetic materials. HF-Mg shows less corrosion and is degraded by phagocytosis. However, the application of membranes did not result in higher bone regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.