ArticleHealthcare (Basel, Switzerland)2020
The Effects of Long-Term 40-Hz Physioacoustic Vibrations on Motor Impairments in Parkinson's Disease: A Double-Blinded Randomized Control Trial.
Article in Healthcare (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Rhythmic auditory stimulation promotes gait recovery in Parkinson's patients: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Aberrant Gamma Oscillations in Parkinson's Disease.Neuroscience bulletin · 2026Review
- Dissecting Motor Domain Responses to Vibration Therapy in Parkinson's Disease: A Systematic Review and Meta-Regression Protocol.Neurology and therapy · 2026Review
- Psychophysiological effects of low-frequency sound mediated by room size, room shape, and stimulus duration.Frontiers in cognition · 2026Article
- A locus coeruleus-centric framework for novelty, salience, and gamma oscillations: implications for neurostimulation, aging, and disease.Frontiers in aging neuroscience · 2026Article
- Effects of Whole-Body, Local, and Modality-Specific Vibration Therapy on Gait in Parkinson's Disease: A Systematic Review and Meta-Analysis.Biomedicines · 2025Review
- Mystery of gamma wave stimulation in brain disorders.Molecular neurodegeneration · 2024Review
- Adenosine mediates the amelioration of social novelty deficits during rhythmic light treatment of 16p11.2 deletion female mice.Molecular psychiatry · 2024Article
- Effects of Vibroacoustic Stimulation on Psychological, Physiological, and Cognitive Stress.Sensors (Basel, Switzerland) · 2024Article
- Audiovisual gamma stimulation for the treatment of neurodegeneration.Journal of internal medicine · 2024Review
- Effects of Geometric Sound on Brainwave Activity Patterns, Autonomic Nervous System Markers, Emotional Response, and Faraday Wave Pattern Morphology.Evidence-based complementary and alternative medicine : eCAM · 2024Article
- Identification and Illustration of Means to a Critical Assessment of Music and Health Research Literature.Healthcare (Basel, Switzerland) · 2023Article
- Vibrotactile stimulation at gamma frequency mitigates pathology related to neurodegeneration and improves motor function.Frontiers in aging neuroscience · 2023Article
- Binaural acoustic stimulation in patients with Parkinson's disease.Frontiers in neurology · 2023Article
- Mechanisms behind the Development of Chronic Low Back Pain and Its Neurodegenerative Features.Life (Basel, Switzerland) · 2022Review
- Deep Brain Stimulation and Microelectrode Recording for the Treatment of Parkinson's Disease.Cureus · 2022Review
- Influence of 40 Hz and 100 Hz Vibration on SH-SY5Y Cells Growth and Differentiation-A Preliminary Study.Molecules (Basel, Switzerland) · 2022Article
- Article
- Exploring a New Cueing Device in People Who Experience Freezing of Gait: Acceptance of a Study Design.Parkinson's disease · 2022Article
- Tactile Low Frequency Vibration in Dementia Management: A Scoping Review.Frontiers in psychology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Recent studies have suggested that vibration therapy may have a positive influence in treating motor symptoms of Parkinson's disease (PD). However, quantitative evidence of the benefits of vibration utilized inconsistent methods of vibration delivery, and to date there have been no studies showing a long-term benefit of 40 Hz vibration in the PD population. The objective of this study was to demonstrate the efficacy of vibration administered via a physioacoustic therapy method (PAT) on motor symptoms of PD over a longer term, completed as a randomized placebo-controlled trial. Overall motor symptom severity measured by the Unified Parkinson's Disease Rating Scale III showed significant improvements in the treatment group over 12 weeks. Specifically, all aspects of PD, including tremor, rigidity, bradykinesia, and posture and gait measures improved. To our knowledge, this is the first study to quantitatively assess 40-Hz vibration applied using the PAT method for potential long-term therapeutic effects on motor symptoms of PD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.