Evidence map›Paper›PMID 32353944›Full record

ArticleBioengineering (Basel, Switzerland)2020

In Vitro Characterization of a Novel Human Acellular Dermal Matrix (BellaCell HD) for Breast Reconstruction.

Sun-Young Nam, Dayoung Youn, Gyeong Hoe Kim, Ji Hwa Chai, Hyang Ran Lim, Hong Hee Jung, Chan Yeong Heo

Open access · goldAbstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sun-Young NamDepartment of Plastic & Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam 13620, Korea.
Dayoung YounDepartment of Plastic & Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam 13620, Korea.
Gyeong Hoe KimDepartment of Plastic and Reconstructive Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea.
Ji Hwa ChaiThe Institute of Tissue Engineering, HansBiomed Co. LTD., Daejeon 34054, Korea.
Hyang Ran LimThe Institute of Tissue Engineering, HansBiomed Co. LTD., Daejeon 34054, Korea.
Hong Hee JungThe Institute of Tissue Engineering, HansBiomed Co. LTD., Daejeon 34054, Korea.
Chan Yeong HeoDepartment of Plastic & Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam 13620, Korea.ORCID 0000-0001-9003-7365
Seoul National University Bundang Hospital · KRSeoul National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the past, acellular dermal matrices (ADMs) have been used in implant-based breast reconstruction. Various factors affect the clinical performance of ADMs since there is a lack of systematic characterization of ADM tissues. This study used BellaCell HD and compared it to two commercially available ADMs-AlloDerm Ready to Use (RTU) and DermACELL-under in vitro settings. Every ADM was characterized to examine compatibility through cell cytotoxicity, proliferation, and physical features like tensile strength, stiffness, and the suture tensile strength. The BellaCell HD displayed complete decellularization in comparison with the other two ADMs. Several fibroblasts grew in the BellaCell HD with no cytotoxicity. The proliferation level of fibroblasts in the BellaCell HD was higher, compared to the AlloDerm RTU and DermACELL, after 7 and 14 days. The BellaCell HD had a load value of 444.94 N, 22.44 tensile strength, and 118.41% elongation ratio, and they were higher than in the other two ADMs. There was no significant discrepancy in the findings of stiffness evaluation and suture retention strength test. The study had some limitations because there were many other more factors useful in ADM's testing. In the study, BellaCell HD showed complete decellularization, high biocompatibility, low cytotoxicity, high tensile strength, high elongation, and high suture retention strengths. These characteristics make BellaCell HD a suitable tissue for adequate and safe use in implant-based breast reconstruction in humans.

Indexed as

acellular dermal matrixAlloDerm RTUBellaCell HDDermACELL

Identifiers

PMID32353944
PMCPMC7356368
OpenAlexW3022443083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.