ArticleAging2020
The relation of poor mastication with cognition and dementia risk: a population-based longitudinal study.
Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07180147 (Arlington Longitudinal Optimal Healthy Aging Study), which is not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Arlington Longitudinal Optimal Healthy Aging Study (ALOHA)
Who cites it
15 citing papers in PubMed.
- [Age-Related Changes in Occlusion and the Clinical Management and Prevention Strategies].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Association between masticatory function and cognitive ability in mild cognitive impairment.BMC geriatrics · 2026Article
- Association between reduced chewing-induced brain blood flow and cognitive performance in mandibular prognathism patients in a pilot study.Scientific reports · 2026Article
- Alzheimer's Disease and Oral Health from Clinical Challenges to Interdisciplinary Care: A Narrative Review.Journal of clinical medicine · 2025Review
- Oral function improvement through oral exercise: gender differences in community-dwelling older adults.BMC geriatrics · 2025Article
- Associations between oral health measures and cognitive function in middle aged and older Indian adults.Scientific reports · 2025Article
- Association of tooth location, occlusal support and chewing ability with cognitive decline and incident dementia.Journal of clinical periodontology · 2025Article
- Longitudinal association between posterior occlusal contact and dementia development in a large retrospective cohort study using a Japanese claims database.Scientific reports · 2024Article
- Poor Oral Health Is Associated With Inflammation, Aortic Valve Calcification, and Brain Volume Among Forager-Farmers.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Risk factors of cognitive impairment: Impact of decline in oral function.The Japanese dental science review · 2023Review
- Influence of Age on Associations of Occlusal Status and Number of Present Teeth with Dementia in Community-Dwelling Older People in Japan: Cross-Sectional Study.International journal of environmental research and public health · 2023Article
- Article
- Sedentary Life and Reduced Mastication Impair Spatial Learning and Memory and Differentially Affect Dentate Gyrus Astrocyte Subtypes in the Aged Mice.Frontiers in neuroscience · 2021Article
- Oral health of individuals with dementia and Alzheimer's disease: A review.Journal of Indian Society of PeriodontologyReview
- Association between occlusal support, salivary amyloid-β42 levels, and cognitive function in older adults: A cross-sectional pilot study.Journal of Alzheimer's disease reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
We investigated the effect of poor masticatory ability on cognitive trajectories and dementia risk in older adults. 544 cognitively intact adults aged ≥50 were followed for up to 22 years. Cognitive domains (verbal, spatial/fluid, memory, and perceptual speed) were assessed at baseline and follow-ups. Dementia was ascertained according to standard criteria. Masticatory ability was assessed using the Eichner Index and categorized according to the number of posterior occlusal zones: A (all four), B (3-1), and C (none).At baseline, 147 (27.0%) participants were in Eichner category A, 169 (31.1%) in B and 228 (41.9%) in C. After the age of 65, participants in Eichner category B and C showed an accelerated decline in spatial/fluid abilities (β: -0.16, 95% CI: -0.30 to -0.03) and (β: -0.15, 95% CI: -0.28 to -0.02), respectively. Over the follow-up, 52 incident dementia cases were identified. Eichner categories B or C were not associated with an increased risk of dementia, compared to category A (Hazard Ratio [HR]: 0.83, 95% CI: 0.39 to 1.76 and HR: 0.63, 95% CI: 0.30 to 1.29, respectively).Poor masticatory ability is associated with an accelerated cognitive decline in fluid/spatial abilities, however it was not related to a higher risk of dementia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.