Evidence map›Paper›PMID 32353761›Full record

SynthesisJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2020

Supportive Treatment with Tocilizumab for COVID-19: A Systematic Review.

Saeed K Alzghari, Valerie S Acuña

Registry-linked trialAbstract readSystematic Review
In one paragraph

Synthesis in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04423042 (A Nested Interventional Cohort Study to Assess the Efficacy and Safety of Adjunctive Humanized Monoclonal Interleukin-6 Receptor Blocker Tocilizumab), which is not on this map. Cited by 82 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04423042 phase3unknown statusnot on this map

A Nested Interventional Cohort Study to Assess the Efficacy and Safety of Adjunctive Humanized Monoclonal Interleukin-6 Receptor Blocker Tocilizumab (TCZ) Therapy to Standard of Care for the Reduction of Hyperinflammation Related Mortality in SARS-Cov2 Positive Patients

TypeinterventionalSponsorUniversity of CalgaryRan2020 to 2021Enrolled30ConditionsCovid19, COVID-19, Severe Acute Respiratory Syndrome Coronavirus 2, CoronavirusArmsTocilizumab
3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. COVID-19 pneumonia treated with ultra-low doses of radiotherapy (ULTRA-COVID study): a single institution report of two cases.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021
    Trial
  5. Trial
  6. Phytocompounds of Honey mesquite (In silico pharmacology · 2025
    Article
  7. Review
  8. Antiviral Therapy of COVID-19.International journal of molecular sciences · 2023
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Saeed K AlzghariDepartment of Pharmacy, Baylor Scott & White Medical Center, Waxahachie, TX, United States; Department of Pharmacotherapy, University of North Texas Health Science Center College of Pharmacy, Fort Worth, TX, United States; Department of Pharmacy Practice, Texas Tech University Health Sciences Center Jerry H. Hodge School of Pharmacy, Dallas, TX, United States. Electronic address: saeed.alzghari1@bswhealth.org.
Valerie S AcuñaDepartment of Pharmacotherapy, University of North Texas Health Science Center College of Pharmacy, Fort Worth, TX, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antibodies, Monoclonal, HumanizedBetacoronavirusCoronavirus InfectionsCOVID-19HumansPandemicsPneumonia, ViralSARS-CoV-2Antibodies, Monoclonal, Humanizedtocilizumab

Identifiers

PMID32353761
PMCPMC7194791

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.