Evidence map›Paper›PMID 32353337›Full record

ReviewTrends in neurosciences2020

Imaging Brain Metabolism Using Hyperpolarized

Lydia M Le Page, Caroline Guglielmetti, Celine Taglang, Myriam M Chaumeil

Open access · hybridAbstract readReview
In one paragraph

Review in Trends in neurosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. HyperpolarizedResearch square · 2026
    Article
  3. Review
  4. Article
  5. Increasing Infusion Times of Hyperpolarized [1-Magnetic resonance in medicine · 2026
    Article
  6. Article
  7. Article
  8. The journal of physical chemistry. B · 2025
    Article
  9. Scalable Hyperpolarized MRI Enabled by Ace-SABRE of [1-Angewandte Chemie (International ed. in English) · 2025
    Article
  10. Tracking Hyperpolarized [1-NMR in biomedicine · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Structural and functional imaging of brains.Science China. Chemistry · 2023
    Review
  18. Multinuclear MRI in Drug Discovery.Molecules (Basel, Switzerland) · 2022
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lydia M Le PageDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Caroline GuglielmettiDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Celine TaglangDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Myriam M ChaumeilDepartment of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. Electronic address: myriam.chaumeil@ucsf.edu.
American Physical Therapy Association · USUniversity of California, San Francisco · US

Funding

Understand and probing disrupted glucose metabolism in Alzheimer's diseaseRF1AG064170 · NIA · J. DAVID GLADSTONE INSTITUTES · PI CHAUMEIL, MYRIAM MARIANNE, NAKAMURA, KEN · 2019 to 2019
$3.6M
MR Metabolic Imaging of Multiple SclerosisR01NS102156 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jeremy William Gordon, Ari J Green · 2017 to 2026
$3.4M
Application of Hyperpolarized 13C Magnetic Resonance Imaging to Detect Target Inhibition of NF-kB Activation and Response in Primary CNS LymphomaR01CA239462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAUMEIL, MYRIAM MARIANNE, RUBENSTEIN, JAMES LOUIS · 2019 to 2023
$3.1M
In vivo metabolic imaging of neuroinflammation after TBIR21NS096718 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAUMEIL, MYRIAM MARIANNE, ROSI, SUSANNA · 2016 to 2017
$436k
NCI NIH HHS R01 CA239462NIA NIH HHS RF1 AG064170NINDS NIH HHS R01 NS102156NINDS NIH HHS R21 NS096718
6 · The paper itself

Abstract

Aberrant metabolism is a key factor in many neurological disorders. The ability to measure such metabolic impairment could lead to improved detection of disease progression, and development and monitoring of new therapeutic approaches. Hyperpolarized

Indexed as

Magnetic Resonance ImagingNeuroimagingBrainHumansMagnetic Resonance Spectroscopyclinical translationhyperpolarized (13)C magnetic resonance spectroscopyimmunometabolismmetabolic imagingMRIneurological disorderspreclinical models

Identifiers

PMID32353337
PMCPMC7255622
OpenAlexW3015750663

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.