ArticleImmunity2020
The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans.
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Article in Immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers.
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139citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
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Who cites it
139 citing papers in PubMed, 206 citations in OpenAlex.
- Elevated CD21Journal of clinical immunology · 2022Trial
- Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans.Cell reports · 2021Trial
- Impaired memory B-cell recall responses in the elderly following recurrent influenza vaccination.PloS one · 2021Trial
- B cell analysis in SARS-CoV-2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID-19.Journal of leukocyte biology · 2021Trial
- Expression patterns of CD24 and CD27 resolve the origins and gradual differentiation of CD11cThe EMBO journal · 2026Article
- Human Peripheral B Cell Subsets: Evolving notions about B cell biology and the broad relevance of B cells in disease.Immunological reviews · 2026Review
- The Developmental and Functional Implications of Age-Associated B Cells (ABCs) Across Tissue Microenvironments.Immunological reviews · 2026Review
- mRNA-based influenza vaccine expands the B cell response breadth in humans.Nature immunology · 2026Observational
- Interferon-Mediated Regulation of Memory B Cell Identity and Function.Immunological reviews · 2026Review
- Polymorphonuclear Myeloid-Derived Suppressor Cells Promote Rheumatoid Arthritis by Inducing Age-Associated B Cells Proliferation and Differentiation via the BAFF-Mediated SYK-ERK1/2 Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Germinal center-independent memory B cells provide rapid protection from lethal influenza challenges.bioRxiv : the preprint server for biology · 2026Article
- B cell-intrinsic CXCR3 drives efficient generation of ectopic pulmonary germinal center responses to influenza A virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Atypical B cells and inflammatory profiles delineate immunity to influenza vaccination in First Nations and non-Indigenous people with chronic multimorbidity.Nature communications · 2026Article
- SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children.Nature communications · 2026Article
- Spatial characterization of skin lesions in discoid and systemic lupus erythematosus.Nature communications · 2026Article
- Age-associated B cells, key players in autoimmune pathogenesis.Immunity & ageing : I & A · 2026Review
- Molecular Pathogenesis and Therapeutic Response of Diffuse Large B Cell Lymphoma Genetic Subtypes.Annual review of cancer biology · 2026Article
- Article
- Heterogeneous Activated B Cell Compartments Arising Early and Transiently After SARS-CoV-2 Vaccination.European journal of immunology · 2026Article
- Robust effector memory features of human T-betiScience · 2026Article
79 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byT-bet2020
Authors and funding
24 authors at 7 institutions in 1 country.
John L JohnsonDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rebecca L RosenthalDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
James J KnoxDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Arpita MylesDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Martin S NaradikianLa Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
Joanna MadejDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mariya KostivDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Aaron M RosenfeldDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wenzhao MengDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Shannon R ChristensenDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Scott E HensleyDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jonathan YewdellLaboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
David H CanadayDivision of Infectious Disease, Case Western Reserve University School of Medicine, and Cleveland VA Hospital, Cleveland, OH 45106, USA.
Jinfang ZhuLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Adrian B McDermottVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Yoav DoriCenter for Lymphatic Imaging and Intervention, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Max ItkinDivision of Interventional Radiology, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
E John WherryInstitute for Immunology, Parker Institute for Cancer Immunotherapy at University of Pennsylvania, and Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, 19104, USA.
Norbert PardiDepartment of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Drew WeissmanDepartment of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ali NajiDepartment of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
Eline T Luning PrakDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Michael R BettsDepartment of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Michael P CancroDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: cancro@pennmedicine.upenn.edu.
University of Pennsylvania · USNational Institutes of Health · USHospital of the University of Pennsylvania · USCase Western Reserve University · USChildren's Hospital of Philadelphia · USLa Jolla Institute for Immunology · USParker Institute for Cancer Immunotherapy · US
Funding
UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 1985 to 2026
$222.3MVaccine Immunology ProgramZIAAI005143 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KOUP, RICHARD A · 2019 to 2025
$51.8MTranscriptomics and Repertoire ProfilingP01AI106697 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2013 to 2026
$31.3MTranscriptional Regulation of Immune Cell Development, Activation and FunctionsZIAAI001169 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ZHU, JINFANG · 2012 to 2025
$21.8MPenn integrated Human Pancreas procurement and Analysis ProgramUC4DK112217 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BETTS, MICHAEL R, FELDMAN, MICHAEL D · 2016 to 2020
$17.8MMultidisciplinary Training in Cardiovascular BiologyT32HL007954 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DAVIES, PETER FRANCIS · 2000 to 2019
$9.9MTRAINING PROGRAM/RHEUMATIC DISEASEST32AR007442 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI BEHRENS, EDWARD M, MERKEL, PETER A · 1986 to 2018
$5.8MImmune System Development and RegulationT32AI055428 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ALLMAN, DAVID M, OLIVER, PAULA MARIA · 2003 to 2025
$4.2MImpact of prior influenza exposures on antibody repertoires to new viral strainsR01AI108686 · NIAID · WISTAR INSTITUTE · PI HENSLEY, SCOTT ERIC · 2014 to 2022
$3.7MVMD-PhD Training in Infectious Disease-Related ResearchT32AI070077 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Michael Lee Atchison · 2008 to 2026
$3.5MMechanistic studies of BLyS-mediated modulation in HIV-1 Env-specific antibody responsesR01AI118691 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CANCRO, MICHAEL PAUL · 2015 to 2019
$3.4MViral control mechanisms of HIV-specific T cells in HIV-infected lymph nodeR01AI118694 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BETTS, MICHAEL R · 2015 to 2019
$3.3MNCI NIH HHS P30 CA016520NHLBI NIH HHS T32 HL007954NIAID NIH HHS P01 AI106697NIAID NIH HHS R01 AI108686NIAID NIH HHS R01 AI113047NIAID NIH HHS R01 AI118691NIAID NIH HHS R01 AI118694NIAID NIH HHS R21 AI133998NIAID NIH HHS T32 AI055428NIAID NIH HHS T32 AI070077NIAMS NIH HHS T32 AR007442NIDDK NIH HHS UC4 DK112217
Abstract
B cell subsets expressing the transcription factor T-bet are associated with humoral immune responses and autoimmunity. Here, we examined the anatomic distribution, clonal relationships, and functional properties of T-bet
Indexed as
AnimalsAntibodies, NeutralizingAntibody SpecificityB-LymphocytesB-Lymphocyte SubsetsGerminal CenterHIV AntibodiesHumansImmunologic MemoryInfluenza A virusInfluenza, HumanMiceOrgan SpecificityT-bet Transcription FactorT-Box Domain ProteinsAntibodies, NeutralizingHIV AntibodiesT-bet Transcription FactorT-Box Domain ProteinsAge-associated B cellsantibodyB cell memoryBCR sequencinghemagglutinin stalkHumoral immunityimmune repertoire profilinginfluenzaT-bet(+) B cellstissue-resident
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