ArticleBritish journal of clinical pharmacology2020
Real-world evaluation of the impact of statin intensity on adherence and persistence to therapy: A Scottish population-based study.
Article in British journal of clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Statin adherence among patients with hypertension in Swedish primary health care: a QregPV cohort study using explainable machine learning.European heart journal. Cardiovascular pharmacotherapy · 2026Article
- Inflammatory and cholesterol risks and rates of major cardiovascular events among patients with atherosclerotic cardiovascular disease in routine care.European heart journal open · 2026Article
- Divergent Role of Statin Use and Intensity in Patients Undergoing Transcatheter Aortic Valve Replacement.Cardiorenal medicine · 2026Article
- Advances in Non-statin Lipid Therapies: A Narrative Review of Evolving Strategies for Cardiovascular Risk Reduction.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026Review
- Short- and Long-Term Statin Persistence and Determinants in Patients Initiating Statin Therapy.Medeniyet medical journal · 2025Article
- Factors and outcomes associated with adherence to statins among patients with newly diagnosed cardiovascular disease.American journal of preventive cardiology · 2025Article
- Trends in statin utilization and ischemic heart disease mortality in Lithuania and Sweden, 2000-2020.Upsala journal of medical sciences · 2024Article
- Statins use amidst the pandemic: prescribing, dispensing, adherence, persistence, and correlation with COVID-19 statistics in nationwide real-world data from Poland.Frontiers in pharmacology · 2024Article
- Editorial: Medication safety and interventions to reduce patient harm in low- and middle-income countries.Frontiers in pharmacology · 2022Article
- Bempedoic Acid: The New Kid on the Block for the Treatment of Dyslipidemia and LDL Cholesterol: A Narrative Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2021Review
- Real-world evaluation of the impact of statin intensity on adherence and persistence to therapy: A Scottish population-based study.British journal of clinical pharmacology · 2020Article
- Real-World Effectiveness of Therapy With Rosuvastatin Combined With Fenofibric Acid in a Sample of Colombian Patients With Mixed Dyslipidemia.Journal of primary care & community healthObservational
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess associations between statin intensity and adherence, persistence and discontinuation of statin therapy in Scotland.
methodRetrospective cohort study, using linked electronic health records covering a period from January 2009 to December 2016. The study cohort included adult patients (≥18 years) newly initiating statins within Greater Glasgow and Clyde, Scotland. Study outcomes comprised adherence, discontinuation and persistence to treatment, stratified by three exposure groups (high, moderate and low intensity). Discontinuation and persistence were calculated using the refill-gap and anniversary methods, respectively. Proportion of days covered (PDC) was used as a proxy for adherence. Kaplan-Meier survival curves and Cox proportional hazard models were used to evaluate discontinuation, and associations between adherence/persistence and statin intensity were assessed using logistic regression.
resultsA total of 73 716 patients with a mean age of 61.4 ± 12.6 years were included; the majority (88.3%) received moderate intensity statins. Discontinuation rates differed between intensity levels, with high-intensity patients less likely to discontinue treatment compared to those on moderate intensity (prior cardiovascular disease [CVD]: HR 0.43 [95% CI 0.34-0.55]; no prior CVD: 0.80 [0.74-0.86]). Persistence declined over time, and high-intensity patients had the highest persistence rates. Overall, 52.6% of patients were adherent to treatment (PDC ≥ 80%), but adherence was considerably higher among high-intensity patients (63.7%).
conclusionHigh-intensity statins were associated with better persistence and adherence to treatment, but overall long-term persistence and adherence remain a challenge, particularly among patients without prior CVD. This needs addressing.
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