Evidence map›Paper›PMID 32353143›Full record

ArticleEuropean heart journal. Cardiovascular pharmacotherapy2021

Management of patients with combined arterial hypertension and aortic valve stenosis: a consensus document from the Council on Hypertension and Council on Valvular Heart Disease of the European Society of Cardiology, the European Association of Cardiovascular Imaging (EACVI), and the European Association of Percutaneous Cardiovascular Interventions (EAPCI).

Costantino Mancusi, Giovanni de Simone, Jana Brguljan Hitij, Isabella Sudano, Felix Mahfoud, Gianfranco Parati, Thomas Kahan, Emanuele Barbato, Luc A Pierard, Madalina Garbi and 2 more

Open access · bronzeAbstract readConsensus Statement
In one paragraph

Article in European heart journal. Cardiovascular pharmacotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  6. Article
  7. Article
  8. [Impact of elevated arterial blood pressure on bioprosthetic valve calcification and failure after transcatheter aortic valve replacement].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Sex differences in arterial hypertension.European heart journal · 2022
    Review
  17. New Evidence About Aortic Valve Stenosis and Cardiovascular Hemodynamics.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022
    Review
  18. Towards Personalized Therapy of Aortic Stenosis.Journal of personalized medicine · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 7 countries.

Costantino MancusiHypertension Research Center, Federico II University Hospital, Naples, Italy.ORCID 0000-0001-6690-1408
Giovanni de SimoneHypertension Research Center, Federico II University Hospital, Naples, Italy.
Jana Brguljan HitijHypertension Division, Department of Internal Medicine, University Medical Centre Ljubljana, Medical Faculty Ljubljana, Ljubljana, Slovenia.
Isabella SudanoDepartment of Cardiology, University Heart Center Zurich, University Hospital of Zürich, Zürich, Switzerland.
Felix MahfoudDepartment for Cardiology, Angiology, Intensive Medicine, Saarland University Hospital, Homburg/Saar, Germany.
Gianfranco ParatiDepartment of Medicine and Surgery, University of Milano-Bicocca & Istituto Auxologico Italiano, IRCCS, Cardiology Unit, Milan, Italy.ORCID 0000-0001-9402-7439
Thomas KahanDivision of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
Emanuele BarbatoHypertension Research Center, Federico II University Hospital, Naples, Italy.
Luc A PierardDepartment of Cardiology, Heart Valve Clinic, University Hospital Sart-Tilman, Liège, Belgium.
Madalina GarbiRoyal Papworth Hospital NHS Foundation Trust Papworth Road, Cambridge Biomedical Campus, Cambridge, UK.
Frank A FlachskampfDepartment of Medical Sciences, Uppsala University, and Clinical Physiology and Cardiology, Akademiska, Uppsala, Sweden.
Eva GerdtsDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Federico II University Hospital · ITHaukeland University Hospital · NOIRCCS Istituto Auxologico Italiano · ITKarolinska Institutet · SELjubljana University Medical Centre · SIPapworth Hospital NHS Foundation Trust · GBSaarland University · DEUniversity Hospital of Zurich · CHUppsala University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aortic valve stenosis (AS) is the third most common cardiovascular disease. The prevalence of both AS and arterial hypertension increases with age, and the conditions therefore often co-exist. Co-existence of AS and arterial hypertension is associated with higher global left ventricular (LV) pressure overload, more abnormal LV geometry and function, and more adverse cardiovascular outcome. Arterial hypertension may also influence grading of AS, leading to underestimation of the true AS severity. Current guidelines suggest re-assessing patients once arterial hypertension is controlled. Management of arterial hypertension in AS has historically been associated with prudence and concerns, mainly related to potential adverse consequences of drug-induced peripheral vasodilatation combined with reduced stroke volume due to the fixed LV outflow obstruction. Current evidence suggests that patients should be treated with antihypertensive drugs blocking the renin-angiotensin-aldosterone system, adding further drug classes when required, to achieve similar target blood pressure (BP) values as in hypertensive patients without AS. The introduction of transcatheter aortic valve implantation has revolutionized the management of patients with AS, but requires proper BP management during and following valve replacement. The purpose of this document is to review the recent evidence and provide practical expert advice on management of hypertension in patients with AS.

Indexed as

Aortic Valve StenosisCardiologyHeart Valve DiseasesHypertensionHumansAortic valve calcificationAortic valve replacementAortic valve stenosisArterial hypertensionCardiovascular riskDrug therapyLeft ventricular hypertrophyPrognosis

Identifiers

PMID32353143
PMCPMC13453065
OpenAlexW3021182885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.