Evidence map›Paper›PMID 32353011›Full record

ArticlePloS one2020

Cost-effectiveness of psychological treatments for post-traumatic stress disorder in adults.

Ifigeneia Mavranezouli, Odette Megnin-Viggars, Nick Grey, Gita Bhutani, Jonathan Leach, Caitlin Daly, Sofia Dias, Nicky J Welton, Cornelius Katona, Sharif El-Leithy and 3 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Ifigeneia MavranezouliCentre for Outcomes Research and Effectiveness, Research Department of Clinical, Educational & Health Psychology, University College London, London, United Kingdom.ORCID 0000-0001-9095-3566
Odette Megnin-ViggarsCentre for Outcomes Research and Effectiveness, Research Department of Clinical, Educational & Health Psychology, University College London, London, United Kingdom.
Nick GreySussex Partnership NHS Foundation Trust, Hove, United Kingdom.
Gita BhutaniLancashire & South Cumbria NHS Foundation Trust, Preston, United Kingdom.
Jonathan LeachDavenal House Surgery, Bromsgrove, United Kingdom.
Caitlin DalyPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Sofia DiasPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.ORCID 0000-0002-2172-0221
Nicky J WeltonPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Cornelius KatonaHelen Bamber Foundation, London, United Kingdom.
Sharif El-LeithyTraumatic Stress Service, Springfield Hospital, London, United Kingdom.
Neil GreenbergKing's Centre for Military Health Research, King's College London, London, United Kingdom.ORCID 0000-0003-4550-2971
Sarah StocktonNational Guideline Alliance, Royal College of Obstetricians and Gynaecologists, London, United Kingdom.
Stephen PillingCentre for Outcomes Research and Effectiveness, Research Department of Clinical, Educational & Health Psychology, University College London, London, United Kingdom.
Royal College of Obstetricians and Gynaecologists · GBUniversity of Bristol · GBHelen Bamber Foundation · GBKing's College London · GBSpringfield Hospital · GBUniversity of Liverpool · GBUniversity of Sussex · GB

Funding

Medical Research Council MR/M005615/1
6 · The paper itself

Abstract

backgroundPost-traumatic stress disorder (PTSD) is a severe and disabling condition that may lead to functional impairment and reduced productivity. Psychological interventions have been shown to be effective in its management. The objective of this study was to assess the cost-effectiveness of a range of interventions for adults with PTSD.

methodsA decision-analytic model was constructed to compare costs and quality-adjusted life-years (QALYs) of 10 interventions and no treatment for adults with PTSD, from the perspective of the National Health Service and personal social services in England. Effectiveness data were derived from a systematic review and network meta-analysis. Other model input parameters were based on published sources, supplemented by expert opinion.

resultsEye movement desensitisation and reprocessing (EMDR) appeared to be the most cost-effective intervention for adults with PTSD (with a probability of 0.34 amongst the 11 evaluated options at a cost-effectiveness threshold of £20,000/QALY), followed by combined somatic/cognitive therapies, self-help with support, psychoeducation, selective serotonin reuptake inhibitors (SSRIs), trauma-focused cognitive behavioural therapy (TF-CBT), self-help without support, non-TF-CBT and combined TF-CBT/SSRIs. Counselling appeared to be less cost-effective than no treatment. TF-CBT had the largest evidence base.

conclusionsA number of interventions appear to be cost-effective for the management of PTSD in adults. EMDR appears to be the most cost-effective amongst them. TF-CBT has the largest evidence base. There remains a need for well-conducted studies that examine the long-term clinical and cost-effectiveness of a range of treatments for adults with PTSD.

Indexed as

AdultCognitive Behavioral TherapyCost-Benefit AnalysisEnglandEye Movement Desensitization ReprocessingFemaleHumansMalePsychotherapyQuality-Adjusted Life YearsSelective Serotonin Reuptake InhibitorsState MedicineStress Disorders, Post-TraumaticSelective Serotonin Reuptake Inhibitors

Identifiers

PMID32353011
PMCPMC7192458
OpenAlexW3018947259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.