ArticleAmerican journal of respiratory and critical care medicine2020
Whole-Blood RNA Profiles Associated with Pulmonary Arterial Hypertension and Clinical Outcome.
Open access · hybridAbstract readValidation Study
In one paragraph
Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease.American journal of respiratory and critical care medicine · 2023Pooled it
- Development of a peripheral blood transcriptomic gene signature to predict bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2023Trial
- Smoking-Related Clinical and Molecular Abnormalities in Idiopathic Pulmonary Fibrosis-Associated Pulmonary Hypertension.Pulmonary circulation · 2026Article
- A circulating MicroRNA signature for the diagnosis of pulmonary arterial hypertension and functional characterization of candidate miR-3168.Scientific reports · 2026Article
- Inflammation and Obesity Correlate in Pulmonary Hypertension but Are Associated with Diverging Outcomes.American journal of respiratory and critical care medicine · 2026Article
- Machine learning-based prediction of IVF/ICSI outcomes in male factor infertility highlighting couple-level BMI.Frontiers in endocrinology · 2026Article
- Endoglin as a BMP9 co-receptor in vascular endothelial cells: prodomain displacement and TGFBRII recruitment.Nature communications · 2025Article
- BMP9 knockout impairs pulmonary vessel muscularisation and confers aberrant tamoxifen sensitivity.Angiogenesis · 2025Article
- Lung Single-Cell Transcriptomics Reveal Diverging Pathobiology and Opportunities for Precision Targeting in Scleroderma-Associated Versus Idiopathic Pulmonary Arterial Hypertension.Circulation. Genomic and precision medicine · 2025Article
- Mechanisms and treatment of pulmonary arterial hypertension.Nature reviews. Cardiology · 2025Review
- SMAD5 as a novel gene for familial pulmonary arterial hypertension.Clinical science (London, England : 1979) · 2025Article
- Reversal of inflammatory reprogramming by vasodilator agents in pulmonary hypertension.ERJ open research · 2025Article
- Machine learning-based integration develops an immune-derived signature for diagnosing high-altitude pulmonary hypertension.Frontiers in medicine · 2025Article
- Exploring Smad5: a review to pave the way for a deeper understanding of the pathobiology of common respiratory diseases.Molecular medicine (Cambridge, Mass.) · 2024Review
- Circulating biomarkers in pulmonary arterial hypertension: State-of-the-art review and future directions.JHLT open · 2024Review
- Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension.Circulation · 2024Article
- The role of polyamine metabolism in cellular function and physiology.American journal of physiology. Cell physiology · 2024Review
- Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response.Nature cardiovascular research · 2024Article
- Association between plasma proteome and pulmonary heart disease: A two-stage Mendelian randomization analysis.The clinical respiratory journal · 2024Article
- Extraction of high quality and high yield RNA from frozen EDTA blood.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
31 authors at 16 institutions in 3 countries.
Christopher J RhodesNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Pablo Otero-NúñezNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
John WhartonNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0001-8110-2575
Emilia M SwietlikDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Sokratis KariotisSheffield Institute for Translational Neuroscience.
Lars HarbaumNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Mark J DunningSheffield Bioinformatics Core, The University of Sheffield, Sheffield, United Kingdom.
Jason M ElinoffCritical Care Medicine Department, NIH Clinical Center, Bethesda, Maryland.
Niamh ErringtonSheffield Institute for Translational Neuroscience.
A A Roger ThompsonDepartment of Infection, Immunity & Cardiovascular Disease, and.
James IremongerDepartment of Infection, Immunity & Cardiovascular Disease, and.
J Gerry CoghlanUniversity College London, London, United Kingdom.
Paul A CorrisNewcastle University, Newcastle upon Tyne, United Kingdom.
Luke S HowardNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
David G KielyDepartment of Infection, Immunity & Cardiovascular Disease, and.
Colin ChurchUniversity of Glasgow, Glasgow, United Kingdom.
Joanna Pepke-ZabaRoyal Papworth Hospital, Cambridge, United Kingdom.
Mark ToshnerDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Stephen J WortNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Ankit A DesaiIndiana University, Indianapolis, Indiana.
Marc HumbertUniversité Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
William C NicholsDivision of Human Genetics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Laura SouthgateMolecular and Clinical Sciences Research Institute, St. George's University of London, London, United Kingdom.ORCID 0000-0002-2090-1450
David-Alexandre TrégouëtINSERM UMR_S 1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
Richard C TrembathDivision of Genetics and Molecular Medicine, King's College London, London, United Kingdom.
Inga ProkopenkoDepartment of Clinical and Experimental Medicine, University of Surrey, Guildford, United Kingdom; and.
Stefan GräfDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-1315-8873
Nicholas W MorrellDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Dennis WangSheffield Institute for Translational Neuroscience.
Allan LawrieDepartment of Infection, Immunity & Cardiovascular Disease, and.
Martin R WilkinsNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0003-3926-1171
Imperial College London · GBImmunité et Cancer · FRUniversity of Cambridge · GBUniversity of Sheffield · GBCincinnati Children's Hospital Medical Center · USIndiana University – Purdue University Indianapolis · USKing's College London · GBNational Institutes of Health Clinical Center · USNewcastle University · GBPapworth Hospital · GBSt George's, University of London · GBUniversité de Bordeaux · FRUniversité Paris-Sud · FRUniversity College London · GBUniversity of Glasgow · GBUniversity of Surrey · GB
Funding
National Biological Sample and Data Repository for PAHR24HL105333 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI NICHOLS, WILLIAM C · 2012 to 2016
$10.1MPathogenic Role of IL-18 in Sickle Cell Cardiomyopathy and Inducible Ventricular TachycardiaR01HL136603 · NHLBI · UNIVERSITY OF ARIZONA · PI DESAI, ANKIT A · 2017 to 2021
$2.4MDevelopment of a Pre-Clinical Rodent Model of Pulmonary Arterial HypertensionZIACL090059 · CLC · CLINICAL CENTER · PI ELINOFF, JASON MATTHEW · 2019 to 2022
$0kBritish Heart Foundation FS/15/59/31839British Heart Foundation FS/18/13/33281British Heart Foundation FS/18/52/33808British Heart Foundation SP/18/10/33975Medical Research Council MR/K020919/1NHLBI NIH HHS R01 HL136603NHLBI NIH HHS R24 HL105333Wellcome Trust
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdultCohort StudiesFamilial Primary Pulmonary HypertensionFemaleGene Expression ProfilingHumansMaleMendelian Randomization AnalysisMiddle AgedRNARNApulmonary arterial hypertensionRNAseqwhole-blood RNA
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.