Evidence map›Paper›PMID 32352748›Full record

ArticleACS applied materials & interfaces2020

Extracellular Matrix/Amorphous Magnesium Phosphate Bioink for 3D Bioprinting of Craniomaxillofacial Bone Tissue.

Nileshkumar Dubey, Jessica A Ferreira, Jos Malda, Sarit B Bhaduri, Marco C Bottino

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Construction of ZnGels (Basel, Switzerland) · 2026
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  10. Bilayer gelatin-methacryloyl scaffold for pulp inflammation suppression and dentin-like tissue regeneration.Journal of controlled release : official journal of the Controlled Release Society · 2026
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  16. Guidance on biomaterials for periodontal tissue regeneration: Fabrication methods, materials and biological considerations.Dental materials : official publication of the Academy of Dental Materials · 2025
    Review
  17. Article
  18. Biofabrication - Revolutionizing the future of regenerative periodontics.Dental materials : official publication of the Academy of Dental Materials · 2025
    Review
  19. Review
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Nileshkumar DubeyDepartment of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109-1078, United States.
Jessica A FerreiraDepartment of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109-1078, United States.ORCID http://orcid.org/0000-0002-9669-4339
Jos MaldaRegenerative Medicine Center, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.ORCID http://orcid.org/0000-0002-9241-7676
Sarit B BhaduriDepartment of Mechanical, Industrial and Manufacturing Engineering and Surgery (Dentistry), University of Toledo, Toledo, Ohio 43606, United States.
Marco C BottinoDepartment of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109-1078, United States.ORCID http://orcid.org/0000-0001-8740-2464
University of Michigan · USU.S. National Science Foundation · USUtrecht University · NL

Funding

NOVEL THERAPEUTICS TO TREAT NECROTIC TEETH: THE COMBINATORIAL EFFECT OF A 3D DRUG DELIVERY SYSTEM AND SPATIALLY DESIGNED STEM CELL NICHESR01DE026578 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOTTINO, MARCO C · 2017 to 2021
$1.7M
A Novel Multilayered Membrane for Periodontal RegenerationK08DE023552 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOTTINO, MARCO C · 2013 to 2017
$716k
NIDCR NIH HHS K08 DE023552NIDCR NIH HHS R01 DE026578
6 · The paper itself

Abstract

Bioprinting, a promising field in regenerative medicine, holds great potential to create three-dimensional, defect-specific vascularized bones with tremendous opportunities to address unmet craniomaxillofacial reconstructive challenges. A cytocompatible bioink is a critical prerequisite to successfully regenerate functional bone tissue. Synthetic self-assembling peptides have a nanofibrous structure resembling the native extracellular matrix (ECM), making them an excellent bioink component. Amorphous magnesium phosphates (AMPs) have shown greater levels of resorption while maintaining high biocompatibility, osteoinductivity, and low inflammatory response, as compared to their calcium phosphate counterparts. Here, we have established a novel bioink formulation (ECM/AMP) that combines an ECM-based hydrogel containing 2% octapeptide FEFEFKFK and 98% water with AMP particles to realize high cell function with desirable bioprintability. We analyzed the osteogenic differentiation of dental pulp stem cells (DPSCs) encapsulated in the bioink, as well as

Indexed as

InkAnimalsBioprintingBone RegenerationCell DifferentiationExtracellular MatrixHydrogelsMagnesium CompoundsMaleOsteogenesisPhosphatesPrinting, Three-DimensionalProof of Concept StudyRats, Inbred F344SkullStem CellsHydrogelsMagnesium Compoundsmagnesium phosphatePhosphatesamorphous magnesium phosphatebioinkbioprintingboneregeneration

Identifiers

PMID32352748
PMCPMC7364626
OpenAlexW3023696986

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.