ArticleClinical and translational gastroenterology2020
The Long-Term Clinical and Endoscopic Outcomes of Cronkhite-Canada Syndrome.
Article in Clinical and translational gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Cronkhite-Canada syndrome: An elusive gastrointestinal disorder with multisystem involvement-pathogenesis, diagnosis, and therapeutic strategies.World journal of gastrointestinal pathophysiology · 2026Review
- Cronkhite-Canada Syndrome: A Diagnostic Challenge and Management With Vedolizumab.The American journal of case reports · 2026Article
- Cronkhite-Canada syndrome after corticosteroid and mesalazine treatment: A case report and 3-year follow-up.Medicine · 2026Article
- Case Report: A case of Cronkhite-Canada syndrome associated with sigmoid colon cancer and early esophageal cancer.Frontiers in medicine · 2026Article
- Cronkhite-Canada Syndrome Presenting as Diarrhea and Weight Loss: A Case Report and Literature Review.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025Review
- A Case of Asymptomatic Cronkhite-Canada Syndrome Diagnosed by Endoscopic and Pathological Findings.Cureus · 2025Article
- Efficacy and safety of azathioprine in patients with Cronkhite-Canada syndrome: a case series from Peking Union Medical College Hospital.BMC pharmacology & toxicology · 2024Article
- Cronkhite-Canada syndrome complicated with pulmonary embolism: A case report.World journal of clinical cases · 2024Article
- Cronkhite-Canada Syndrome With Advanced Gastric Cancer.ACG case reports journal · 2024Article
- Cronkhite-Canada Syndrome: A Rare Cause of Gastrointestinal Polyposis With Response to Emerging Therapy.ACG case reports journal · 2024Article
- Cronkhite-Canada syndrome with esophagus involvement and six-year follow-up: A case report.World journal of gastroenterology · 2024Article
- Cronkhite‒Canada syndrome as inflammatory hamartomatous polyposis: new evidence from whole transcriptome sequencing of colonic polyps.Orphanet journal of rare diseases · 2024Article
- Case Report: Cronkhite-Canada syndrome: presentation of a pediatric case and review of the literature.Frontiers in pediatrics · 2024Article
- A case report of Cronkhite-Canada syndrome first encounterd at a hospital in northern Vietnam.Annals of medicine and surgery (2012) · 2023Article
- Thalidomide combined with endoscopy in the treatment of Cronkhite-Canada syndrome: A case report.World journal of clinical cases · 2022Article
- Surgery for Cronkhite-Canada syndrome complicated with intussusception: A case report and review of literature.World journal of gastrointestinal surgery · 2022Article
- Cronkhite-Canada Syndrome Associated With Superficial Esophageal Carcinoma: A Case Report and Literature Review.Frontiers in medicine · 2022Article
- Cronkhite-Canada syndrome with steroid dependency: A case report.World journal of clinical cases · 2021Article
- [Weight loss, diarrhea and dystrophic alterations of the fingernails in an 80-year-old male patient].Der Internist · 2021Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe prognosis of Cronkhite-Canada syndrome (CCS) is considered poor. Despite the recent therapeutic improvements, the survival outcomes and prognostic factors have been less studied. This study aimed to investigate the long-term clinical and endoscopic outcomes of CCS.
methodsThirty-one patients diagnosed since 1999 and followed up for over 6 months were included. Data regarding survival outcomes, clinical symptoms, endoscopic findings, and treatment were collected and analyzed. R (version 3.6.1) was used to perform the survival analyses.
resultsThe median (interquartile range) follow-up time was 42.5 (19.5-85.8) months. The 5-year overall survival (OS) was 87.4%. The maximum gastric polyp size over 2 cm was associated with worse OS (Hazard ratio [HR]: 18, 95% confidence interval [CI]: 1.6-210, P = 0.021). The 3-year relapse-free survival (RFS) after corticosteroid treatment was 66.8%. Age older than 60 years (HR: 7.0, 95% CI: 1.5-33.0, P = 0.015) and maximum gastric polyp size over 2 cm (HR: 6.0, 95% CI: 1.6-23.0, P = 0.009) were associated with worse RFS. Twenty-three patients received follow-up endoscopic examinations, with a median (interquartile range) follow-up time of 29.0 (14.0-53.5) months. Eight (34.8%) and 12 (52.2%) patients achieved complete remission under gastroscopy and colonoscopy, respectively. Colonic lesions showed a tendency of earlier responses compared with gastric lesions (25.0 [11.3-39.8] months vs 31.0 [21.0-39.8] months). DISCUSSION: Patients with CCS usually responded well to glucocorticoids with a fairly good 5-year survival rate. Large gastric polyp was associated with worse OS and RFS, whereas age older than 60 years was another predictor for worse RFS. Diffuse gastrointestinal lesions partly or completely resolved after treatment, and colonic lesions showed a better response than gastric lesions.
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