Evidence map›Paper›PMID 32352581›Full record

ArticleAlcoholism, clinical and experimental research2020

Examining the Relationship Between Self-Reported Drinking and In-Laboratory Drinking and Craving: Is There Concordance?

Kelly S DeMartini, Brian Pittman, John H Krystal, Stephanie S O'Malley, Suchitra Krishnan-Sarin

Open access · greenAbstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kelly S DeMartiniDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut.ORCID 0000-0003-0943-2507
Brian PittmanDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut.
John H KrystalDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut.
Stephanie S O'MalleyDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut.ORCID 0000-0002-1976-2369
Suchitra Krishnan-SarinDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut.
Yale University · US

Funding

Translational Technologies CoreP50AA012870 · NIAAA · YALE UNIVERSITY · PI Matthew J Girgenti · 2001 to 2026
$43.7M
NIAAA NIH HHS P50 AA012870
6 · The paper itself

Abstract

backgroundIn-laboratory drinking sessions that allow direct assessment of drinking and craving are an emerging method for testing novel pharmacotherapy compounds and behavioral interventions for alcohol use disorders. Despite wide implementation, limited evidence supports the concordance between drinking in the laboratory and in a natural setting. This study examined the relationship between self-reports of drinking prior to and drinking and craving during an alcohol drinking paradigm (ADP).

methodsParticipants were adult heavy drinkers (N = 64) who participated in a pharmacotherapy study. Participants completed self-report alcohol assessments and a baseline ADP session prior to any medication administration. Alcohol craving was assessed during priming and ad lib ADP phases. Outcomes were the associations of total drinks consumed in-laboratory and summary drinking measures for the 30 days prior to the ADP and reports of maximum drinks (past year and lifetime). Additional outcomes were the association of self-reported drinking and alcohol craving during the ADP and the concordance between self-report and ADP World Health Organization (WHO) drinking classifications.

resultsNumber of drinking days, average drinks per drinking occasion, and lifetime and past-year maximum drinks were all related to drinking in the laboratory. Heavy drinking days were not related to drinking in the laboratory but were associated with ADP craving. Alcohol craving was also associated with other measures of self-reported drinking. There was also a significant association between WHO drinking risk classification and in-laboratory drinking.

conclusionsThe observed relationships between self-reported drinking and drinking in-laboratory across drinking indices suggest that in-laboratory alcohol consumption may reflect participants' real-world alcohol consumption, supporting the value of laboratory-based drinking paradigms. The demonstrated relationship with self-reported drinking and ADP alcohol craving further supports the value of such paradigms to model key drinking predictors. These results provide support for the validity of laboratory-based paradigms to accurately reflect participants' recent drinking levels.

Indexed as

CravingLaboratoriesSelf ReportAdultAlcohol DrinkingAlcoholismEthanolFemaleHumansMaleRisk FactorsWorld Health OrganizationEthanolAlcoholAlcohol Use DisorderHeavy DrinkingLaboratoryWHO Risk

Identifiers

PMID32352581
PMCPMC10158572
OpenAlexW3022429243

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.