Evidence map›Paper›PMID 32352382›Full record

ArticleeLife2020

SKAP2 is required for defense against

Giang T Nguyen, Lamyaa Shaban, Matthias Mack, Kenneth D Swanson, Stephen C Bunnell, David B Sykes, Joan Mecsas

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Effective macrophage clearance ofbioRxiv : the preprint server for biology · 2026
    Article
  2. Infection and immunity · 2026
    Article
  3. Gain-of-function mutation inbioRxiv : the preprint server for biology · 2026
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  8. INTEGRIN FUNCTION IN LEUKOCYTE-MEDIATED INFLAMMATION-ACTINOPATHIES IN IMMUNE DISEASES.Transactions of the American Clinical and Climatological Association · 2025
    Review
  9. Neutrophil diversity and function in health and disease.Signal transduction and targeted therapy · 2024
    Review
  10. Virulence · 2024
    Review
  11. Article
  12. Supernatant of platelet-Microbiology spectrum · 2024
    Article
  13. Article
  14. Article
  15. Distinctive features and prognostic utility of neutrophil in severe patients withFrontiers in cellular and infection microbiology · 2024
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Giang T NguyenGraduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, United States.ORCID 0000-0002-8967-3396
Lamyaa ShabanGraduate Program in Molecular Microbiology, Tufts Graduate School of Biomedical Sciences, Boston, United States.
Matthias MackDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Kenneth D SwansonBrain Tumor Center and Neuro-Oncology Unit, Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, United States.
Stephen C BunnellGraduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, United States.ORCID 0000-0001-6887-0828
David B SykesCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, United States.
Joan MecsasGraduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, United States.ORCID 0000-0001-9455-6672
Boston University · USBeth Israel Deaconess Medical Center · USMassachusetts General Hospital · USTufts University · USUniversity Hospital Regensburg · DE

Funding

MOLECULAR ANALYSIS OF MICROBIAL PATHOGENST32AI007422 · NIAID · TUFTS UNIVERSITY BOSTON · PI Ralph R. Isberg · 1992 to 2026
$5.7M
Initiation and regulation of antibacterial innate immunityR01AI113166 · NIAID · TUFTS UNIVERSITY BOSTON · PI MECSAS, JOAN C · 2014 to 2018
$2.4M
NIAID NIH HHS R01 AI113166NIAID NIH HHS T32 AI007422
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Respiratory BurstAnimalsBacterial LoadCell LineDisease Models, AnimalFocal Adhesion Kinase 2Intracellular Signaling Peptides and ProteinsKlebsiella InfectionsKlebsiella pneumoniaeLungMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutNeutrophilsPhosphorylationPneumonia, BacterialFocal Adhesion Kinase 2Intracellular Signaling Peptides and ProteinsPtk2b protein, mouseReactive Oxygen Speciessrc kinase associated phosphoprotein 2Syk KinaseSyk protein, mousebacterial pneumoniaHoxb8immunologyinfectious diseaseinflammationKlebsiella pneumoniaemicrobiologymouseneutrophilsreactive oxygen speciesSKAP2

Identifiers

PMID32352382
PMCPMC7250567
OpenAlexW3023707362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.