Evidence map›Paper›PMID 32352376›Full record

ArticleeLife2020

DASC, a sensitive classifier for measuring discrete early stages in clathrin-mediated endocytosis.

Xinxin Wang, Zhiming Chen, Marcel Mettlen, Jungsik Noh, Sandra L Schmid, Gaudenz Danuser

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. VAMP8 function reveals tight linkage between endocytic recycling and endocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Dynamic early recruitment of GAK-Hsc70 regulates coated pit maturation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Imaging nanoscale axial dynamics at the basal plasma membrane.The international journal of biochemistry & cell biology · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. CALM supports clathrin-coated vesicle completion upon membrane tension increase.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  14. Review
  15. Data science in cell imaging.Journal of cell science · 2021
    Review
  16. Functional characterization of 67 endocytic accessory proteins using multiparametric quantitative analysis of CCP dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  17. Novel function for AP-1B during cell migration.Molecular biology of the cell · 2020
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xinxin Wang *Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-7996-9628
Zhiming Chen *Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-2423-101X
Marcel MettlenDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, United States.
Jungsik NohLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, United States.
Sandra L SchmidDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-1690-7024
Gaudenz DanuserLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0001-8583-2014
The University of Texas Southwestern Medical Center · US

Funding

Request for administrative supplement to Parent R01 GM073165 entitled "Mechanisms regulating clathrin-mediated endocytosis"R01GM073165 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI METTLEN, MARCEL BERNARD · 2006 to 2022
$6.8M
The Clathrin Coated Vesicle CycleR01MH061345 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI SCHMID, SANDRA L. · 2010 to 2019
$5.0M
THE CLATHRIN COATED VESICLE CYCLER37MH061345 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI SCHMID, SANDRA L. · 2000 to 2009
$4.7M
Functional causality in regulating cell morphogenesisR35GM136428 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI DANUSER, GAUDENZ · 2020 to 2024
$4.1M
Quantitative Fluorescent Speckle MicroscopyR01GM067230 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI DANUSER, GAUDENZ · 2003 to 2019
$3.3M
Quantitative Fluorescent Speckle MicroscopyU01GM067230 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DANUSER, GAUDENZ · 2008 to 2011
$1.7M
NIGMS NIH HHS R01 GM067230NIGMS NIH HHS R01 GM073165NIGMS NIH HHS R35 GM136428NIGMS NIH HHS U01 GM067230NIH HHS MH61345NIMH NIH HHS R01 MH061345NIMH NIH HHS R37 MH061345Welch Foundation I-1823
6 · The paper itself

Abstract

Clathrin-mediated endocytosis (CME) in mammalian cells is driven by resilient machinery that includes >70 endocytic accessory proteins (EAP). Accordingly, perturbation of individual EAPs often results in minor effects on biochemical measurements of CME, thus providing inconclusive/misleading information regarding EAP function. Live-cell imaging can detect earlier roles of EAPs preceding cargo internalization; however, this approach has been limited because unambiguously distinguishing abortive coats (ACs) from

Indexed as

ClathrinClathrin-Coated VesiclesCoated Pits, Cell-MembraneEndocytosisHumansThermodynamicsClathrincell biologycomputational biologyendocytic accessory proteinsendocytosishumansystems biologyunbiased classification

Identifiers

PMID32352376
PMCPMC7192580
OpenAlexW3023741670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.