Evidence map›Paper›PMID 32351883›Full record

ArticleFrontiers in oncology2020

PIWI-Interacting RNA-004800 Is Regulated by S1P Receptor Signaling Pathway to Keep Myeloma Cell Survival.

Huanxin Ma, Huihan Wang, Fei Tian, Yuan Zhong, Zhuogang Liu, Aijun Liao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 27 citations in OpenAlex.

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  12. Exosomal non-coding RNAs: Emerging roles in bilateral communication between cancer cells and macrophages.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Review
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  15. Noncoding RNAs in tumor metastasis: molecular and clinical perspectives.Cellular and molecular life sciences : CMLS · 2021
    Review
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  18. Emerging functions of piwi-interacting RNAs in diseases.Journal of cellular and molecular medicine · 2021
    Review
  19. Review
  20. Exosomal Non-coding RNAs-Mediated Crosstalk in the Tumor Microenvironment.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Huanxin MaDepartment of Hematology, Shengjing Hospital of China Medical University, Shenyang, China.
Huihan WangDepartment of Hematology, Shengjing Hospital of China Medical University, Shenyang, China.
Fei TianDepartment of Hematology, Shengjing Hospital of China Medical University, Shenyang, China.
Yuan ZhongDepartment of Hematology, Shengjing Hospital of China Medical University, Shenyang, China.
Zhuogang LiuDepartment of Hematology, Shengjing Hospital of China Medical University, Shenyang, China.
Aijun LiaoDepartment of Hematology, Shengjing Hospital of China Medical University, Shenyang, China.
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PIWI-interacting RNA (piRNA) is a kind of non-coding single stranded RNA which plays major roles in epigenetic expressions, genome rearrangement, and regulation of gene and protein. Because piRNAs are abnormally expressed in various cancers, they can be used as novel biomarkers and therapeutic targets. However, the roles of piRNAs in cancer cell growth and survival are not well-known. Here, we are the first to provide evidence that PIWI-interacting RNA-004800 (piR-004800) is overexpressed in both exosomes from multiple myeloma (MM) patients' bone marrow supernatant and primary MM cells. The expression level of piR-004800 is positively correlated with the stages of MM, according to the international staging system (ISS). In MM cell lines, downregulation of piR-004800 induced apoptosis and autophagic cell death. This was accompanied by

Indexed as

cell survivalmultiple myelomaPI3K/Akt/mTORpiRNAS1PR

Identifiers

PMID32351883
PMCPMC7175921
OpenAlexW3017102398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.