ArticleCase reports in hematology2020
Spontaneous Spinal Epidural Hematoma in a Patient on Apixaban for Nonvalvular Atrial Fibrillation.
Article in Case reports in hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Prognostic factors and surgical outcomes of spontaneous spinal epidural haematoma: a systematic review and meta-analysis.Neurosurgical review · 2022Pooled it
- Spontaneous Spinal Epidural Haematoma Associated With Direct Oral Anticoagulants: A Descriptive Systematic Review.Cureus · 2026Review
- Pharmacovigilance study of spinal epidural hematoma reports associated with direct oral anticoagulants and warfarin.Acta neurochirurgica · 2026Article
- Delayed-Onset Hematomas Following Mohs Surgery in Patients Taking a Direct Oral Anticoagulant.Cureus · 2025Article
- Spontaneous Spinal Epidural Hematoma Under Rivaroxaban and Clopidogrel: A Case Report and Literature Review.Open access emergency medicine : OAEM · 2025Article
- A rare case of non-traumatic spinal epidural hematoma in lumbar region associated with apixaban therapy.Journal of thrombosis and thrombolysis · 2021Article
- Spontaneous thoracolumbar epidural hematoma in an apixaban anticoagulated patient.Surgical neurology international · 2021Article
- Spontaneous Spinal Epidural Hematoma Associated With Apixaban Therapy: A Report of two Cases.Cureus · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith the rise in the use of direct oral anticoagulants (DOACs), more hemorrhagic complications are being encountered. Since the first description of a case of spontaneous spinal epidural hematoma (SSEH) related to the utilization of DOACs in 2012, there have been few reports describing a similar association. However, no cases so far have reported an association between SSEHs and apixaban.
conclusionsSpinal hematomas represent surgical emergencies with earlier intervention portending better outcome. Based on the few case reports that point to DOACs as a potential culprit, it appears that a high suspicion index resulting in earlier SSEH diagnosis and intervention is crucial for improved neurological outcome and recovery. Prompt diagnosis remains a challenge, especially that SSEH can mimic cerebrovascular accidents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.