ArticleOxidative medicine and cellular longevity2020
Signs of ROS-Associated Autophagy in Testis and Sperm in a Rat Model of Varicocele.
Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Dose-dependent effect of curcumin nanomicelle on autophagy signaling in testis; a study on normal Wistar rats.Molecular biology reports · 2026Article
- Adipose-derived stem cells-conditioned medium (ADMSCs-CM) improves testicular function and sperm DNA damage via Nrf2 antioxidant signaling pathways in rat unilateral varicocele.Stem cell research & therapy · 2026Article
- Oxidative Stress-Related Programmed Cell Death in Male Infertility: Focussing on Ferroptosis.Journal of cellular and molecular medicine · 2026Review
- Advances in immune-inflammatory interactions within the testicular-penile microenvironment of varicocele patients: molecular mechanisms underlying erectile dysfunction and spermatogenic impairment.Frontiers in endocrinology · 2026Review
- Oxidative Stress-Associated Alterations in Sperm ACTL7A Expression and Function in Men With Varicocele.Oxidative medicine and cellular longevity · 2026Article
- Molecular Remodeling of the Sperm Proteome Following Varicocele Sclero-Embolization: Implications for Semen Quality Improvement.Proteomes · 2025Article
- The Preventive Effect of Zinc Sulfate against Olanzapine-Induced Testicular Toxicity in Male Rats.Biological trace element research · 2025Article
- Protective Effect of Lycopene on Ifosfamide-Induced Mitophagy throughInternational journal of fertility & sterility · 2025Article
- c-Jun N-terminal Kinase Supports Autophagy in Testicular Ischemia but Triggers Apoptosis in Ischemia-Reperfusion Injury.International journal of molecular sciences · 2024Article
- Impact of Varicocele on Testicular Oxidative Stress and Sperm Parameters in Experimental Animals: A Systematic Review and Meta-Analysis.The world journal of men's health · 2024Article
- The constructive and destructive impact of autophagy on both genders' reproducibility, a comprehensive review.Autophagy · 2023Review
- Aberrant Expression of TET2 Accounts for DNA Hypomethylation in Varicocele.Cell journal · 2023Article
- Nano-selenium Alleviates Cadmium-Induced Mouse Leydig Cell Injury, via the Inhibition of Reactive Oxygen Species and the Restoration of Autophagic Flux.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Pre-meiotic deletion of PEX5 causes spermatogenesis failure and infertility in mice.Cell proliferation · 2023Article
- The Synergetic Effect of EgyptianAntioxidants (Basel, Switzerland) · 2022Article
- The NLRP3 inflammasome: molecular activation and regulation in spermatogenesis and male infertility; a systematic review.Basic and clinical andrology · 2022Review
- Article
- Transcutaneous Electrical Acupoint Stimulation Ameliorates Cognitive Function through PINK1/Parkin Mediated Mitophagy in VD Rats.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- New insights into mitophagy and stem cells.Stem cell research & therapy · 2021Review
- Fluorochloridone induces autophagy in TM4 Sertoli cells: involvement of ROS-mediated AKT-mTOR signaling pathway.Reproductive biology and endocrinology : RB&E · 2021Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since autophagy was suspected to occur in the pathological situation of varicocele (VCL), we have attempted to confirm it here using a surgical model of varicocele-induced rats. Thirty Wistar rats were divided into three groups (varicocele/sham/control) and analyzed two months after the induction of varicocele. Testicular tissue sections and epididymal mature sperm were then monitored for classic features of varicocele, including disturbance of spermatogenesis, impaired testicular carbohydrate and lipid homeostasis, decreased sperm count, increased sperm nuclear immaturity and DNA damage, oxidative stress, and lipid peroxidation. At the same time, we evaluated the Atg7 protein content and LC3-II/LC3-1 protein ratio in testis and mature sperm cells, two typical markers of early and late cellular autophagy, respectively. We report here that testis and mature sperm show higher signs of autophagy in the varicocele group than in the control and sham groups, probably to try to mitigate the consequences of VCL on the testis and germ cells.
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