ArticleEvidence-based complementary and alternative medicine : eCAM2020
Evaluation of Antiulcer Activity of 80% Methanol Extract and Solvent Fractions of the Root of
Article in Evidence-based complementary and alternative medicine : eCAM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Gastroprotective effects of chlorella derived lutein via anti-inflammatory antioxidant and acid enzyme modulation.iScience · 2026Article
- Antiulcer activity ofOpen veterinary journal · 2025Review
- Secondary Metabolites fromMetabolites · 2025Review
- Effects ofIranian journal of basic medical sciences · 2024Article
- Gastroprotective Activities of Aqueous and 80% Methanol Leaf Extracts ofJournal of experimental pharmacology · 2023Article
- Analysis of total phenolic contents, flavonoids, antioxidant and antibacterial activities of Croton macrostachyus root extracts.BMC chemistry · 2022Article
- Review of Ethnobotanical and Ethnopharmacological Evidence of Some Ethiopian Medicinal Plants Traditionally Used for Peptic Ulcer Disease Treatment.Clinical and experimental gastroenterology · 2022Review
- Evaluation of the Antiulcer Activity of Methanolic Extract and Solvent Fractions of the Leaves ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Protective Effect and Potential Mechanism of the Traditional Chinese Medicine Shaoyao-Gancao Decoction on Ethanol-Induced Gastric Ulcers in Rats.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Hydromethanolic Crude Extract of the Leaf ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Evaluation of mechanism(s) of action underlying the antioxidant and antiulcer activity of Sesamum indicum leaves extract in experimental rats.Indian journal of pharmacologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeptic ulcer disease causes significant mortality and morbidity. Plant kingdom provides a useful source for the development of new antiulcer agents.
methodsThe crude extract was obtained by cold maceration in 80% methanol and fractionated with chloroform, ethyl acetate, and distilled water. The antiulcer activity was evaluated using pylorus ligation-induced ulcer model in Sprague Dawley rats and acidified ethanol-induced ulcer model in Swiss albino mice. The test groups received three doses (100, 200, and 400 mg/kg) of the crude extract and fractions for 7 days before induction of ulcer. Positive controls received omeprazole 30 mg/kg for the pylorus ligation-induced ulcer model and sucralfate 100 mg/kg for the acidified ethanol-induced ulcer model. Negative controls received vehicle (2% tween 80).
resultsThe crude hydromethanolic extract of
conclusionThe present study demonstrated that the crude extract, chloroform, and ethyl acetate fractions possessed significant dose-dependent antiulcer activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.