Evidence map›Paper›PMID 32351514›Full record

ReviewFrontiers in immunology2020

Immunomodulatory Roles of Polysaccharide Capsules in the Intestine.

Samantha A Hsieh, Paul M Allen

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Synthesis of α,ε-International journal of molecular sciences · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Cellular Effects ofInternational journal of molecular sciences · 2024
    Article
  14. The Plethora of Microbes with Anti-Inflammatory Activities.International journal of molecular sciences · 2024
    Review
  15. A consensus structural motif for the capsular polysaccharide ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Article
  17. Article
  18. Sequestration of gut pathobionts in intraluminal casts, a mechanism to avoid dysregulated T cell activation by pathobionts.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Samantha A HsiehDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States.
Paul M AllenDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States.

Funding

Immune Regulation by Bacteroides Polysaccharide CapsulesR21AI142257 · NIAID · WASHINGTON UNIVERSITY · PI ALLEN, PAUL M, MARTENS, ERIC C · 2019 to 2020
$502k
Initiation of symbiont-driven inflammatory bowel diseases by genetic mutations in T cells and antigen-presenting cellsF30DK114950 · NIDDK · WASHINGTON UNIVERSITY · PI BAI, SAMANTHA HSIEH · 2017 to 2019
$111k
NIAID NIH HHS R21 AI142257NIDDK NIH HHS F30 DK114950
6 · The paper itself

Abstract

The interplay between the immune system and the microbiota in the human intestine dictates states of health vs. disease. Polysaccharide capsules are critical elements of bacteria that protect bacteria against environmental and host factors, including the host immune system. This review summarizes the mechanisms by which polysaccharide capsules from commensal and pathogenic bacteria in the gut microbiota modulate the innate and adaptive immune systems in the intestine. A deeper understanding of the roles of polysaccharide capsules in microbiota-immune interactions will provide a basis to harness their therapeutic potential to advance human health.

Indexed as

ImmunomodulationAdaptive ImmunityAnimalsBacteriaBacterial CapsulesGastrointestinal MicrobiomeHost-Pathogen InteractionsHumansImmunity, InnateImmunity, MucosalIntestinal MucosaMicePolysaccharides, BacterialPolysaccharides, Bacterialadaptive immunityantigen processinginnate immunityintestinal microbiotapolysaccharide capsulesregulatory T cells

Identifiers

PMID32351514
PMCPMC7174666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.