ReviewFrontiers in immunology2020
Innate and Adaptive Immune Responses in HELLP Syndrome.
Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Chronic inflammatory demyelinating polyneuropathy complicated by pre-eclampsia progressing to HELLP syndrome and pulmonary embolism: A case report.Case reports in women's health · 2025Article
- The serum gamma-glutamyl transpeptidase-to-platelet ratio predicts HELLP syndrome.BMC pregnancy and childbirth · 2025Article
- Subcapsular Liver Hematoma Rupture in HELLP Syndrome During Pregnancy: A Case Study and Multidisciplinary Approach.The American journal of case reports · 2024Article
- Maternal immune suppression during pregnancy does not prevent abnormal behavior in offspring.Biology of sex differences · 2024Article
- Value of proteinuria in evaluating the severity of HELLP and its maternal and neonatal outcomes.BMC pregnancy and childbirth · 2023Article
- The role of immune cells and mediators in preeclampsia.Nature reviews. Nephrology · 2023Review
- First-Trimester Screening for HELLP Syndrome-Prediction Model Based on MicroRNA Biomarkers and Maternal Clinical Characteristics.International journal of molecular sciences · 2023Article
- Living with liver disease in the era of COVID-19-the impact of the epidemic and the threat to high-risk populations.World journal of clinical cases · 2022Review
- Haemolysis, elevated liver enzymes and low platelets: Diagnosis and management in critical care.Journal of the Intensive Care Society · 2022Article
- A Rare Case of HELLP Syndrome with Hematomas of Spleen and Liver, Eclampsia, Severe Hypertension and Prolonged Coagulopathy-A Case Report.International journal of environmental research and public health · 2022Article
- Platelet mitochondrial membrane depolarization reflects disease severity in patients with preeclampsia.Molecular medicine (Cambridge, Mass.) · 2022Article
- Clinical Classification, Pregnancy Outcomes and Risk Factors Analysis of Severe Preeclampsia Complicated With HELLP Syndrome.Frontiers in surgery · 2022Article
- Neutrophil-Lymphocyte Ratio as a Screening Test for Preeclampsia in the First and Early-Third Trimesters of Pregnancy: A Cohort Study : Neutrophil-Lymphocyte Ratio and Preeclampsia.Galen medical journal · 2022Article
- The Serotonin-Immune Axis in Preeclampsia.Current hypertension reports · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Innate and adaptive immune involvement in hemolysis, elevated liver enzymes and low platelet (HELLP) syndrome is an understudied field, although it is of high clinical importance. This syndrome implies a risk of serious morbidity and mortality to both the mother and the fetus during pregnancy. It was proposed that HELLP syndrome occurs in a circulatory inflammatory milieu, that might in turn participate in a complex interplay between the secreted inflammatory immunomodulators and immune cell surface receptors. Meanwhile, reported immune cell attenuation during HELLP may consequently lead to a prolonged immunoactivation and tissue damage. In this regard, learning more about the immune components of this syndrome should widen the understanding of the HELLP pathophysiology and eventually enable development of novel immune-based therapeutics. This review aims to summarize and discuss the recent and previous findings of the innate and adaptive immune responses during HELLP in order to update the current knowledge of the immune involvement in HELLP pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.