ArticlePediatric obesity2020
The relationship between pancreas steatosis and the risk of metabolic syndrome and insulin resistance in Chinese adolescents with concurrent obesity and non-alcoholic fatty liver disease.
Article in Pediatric obesity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Association of Incidence between Pancreatic Adipose Infiltration and Metabolic Syndrome: A Literature Review and Meta-analysis.Computational and mathematical methods in medicine · 2021Pooled it
- Free-Breathing Fat Quantification Using a Phase Error-Corrected Cartesian Acquisition With Spiral Profile Ordering.Magnetic resonance in medicine · 2026Article
- Persistently elevated serum gamma-glutamyl transferase is associated with pancreatic cyst development: A sex-stratified propensity score matched multicenter cohort study.Annals of hepato-biliary-pancreatic surgery · 2026Article
- Pancreatic steatosis is associated with exocrine pancreatic dysfunction in children with MASLD: a prospective cross-sectional study.BMC pediatrics · 2026Article
- The spatial heterogeneity of intra-pancreatic fat deposition in children and adolescents with obesity.European journal of pediatrics · 2026Article
- Development and validation of a fully automated transformer-based 3D framework for pancreatic fat quantification in pancreatic steatosis.European journal of radiology open · 2026Article
- Identification of Common Blood Metabolic Derangements Using Magnetic Resonance Signatures of the Pancreas and Liver.Diabetes, obesity & metabolism · 2026Article
- Specific Fat Depots and Cardiometabolic Risk and Insulin Resistance in Children With Obesity.Pediatric obesity · 2026Article
- Aldosterone induced by chronic stress promotes pancreatic steatosis in young male rats.Cell and tissue research · 2026Article
- Microgravity as a translational model for metabolic dysfunction: implications for obesity, insulin resistance, steatotic liver and pancreatic diseases.Frontiers in endocrinology · 2026Review
- Obesity surgery improves metabolic dysfunction-associated steatotic liver disease and type 2 diabetes - MRI and biochemical analysis of liver and pancreas.Surgery open science · 2026Article
- Differential impact of maternal and paternal metabolic syndrome on offspring's cardiometabolic risk factors.Scientific reports · 2025Article
- Understanding the association of intrapancreatic fat deposition with adiposity and components of metabolic syndrome in children and adolescents: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Gamma-glutamyl transferase: A potential biomarker for pancreas steatosis in patients with concurrent obesity, insulin resistance and metabolic dysfunction-associated steatotic liver disease.Clinical obesity · 2025Article
- Determinants of abnormal liver-related biomarkers in adult COVID-19 patients.Frontiers in cellular and infection microbiology · 2025Article
- Non-invasive diagnosis of pancreatic steatosis with ultrasound images using deep learning network.Heliyon · 2024Article
- Obesity, heart failure with preserved ejection fraction, and the role of glucagon-like peptide-1 receptor agonists.ESC heart failure · 2024Review
- Association of pancreatic fat on imaging with pediatric metabolic co-morbidities.Pediatric radiology · 2023Article
- Perirenal fat thickness and liver fat fraction are independent predictors of MetS in adults with overweight and obesity suspected with NAFLD: a retrospective study.Diabetology & metabolic syndrome · 2023Article
- Test-Retest Reliability of a Physical Activity Behavior, Health and Wellbeing Questionnaire in Adolescents.Open research Europe · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of childhood obesity and associated comorbidities are on an increasing trend worldwide. More than 340 million children and adolescents aged between 5 and 19 years old were overweight or had obesity in 2016, from which over 124 million children and adolescents (6% of girls and 8% of boys) had obesity.
objectiveTo describe the relationship between pancreas steatosis, body fat and the risk of metabolic syndrome, insulin resistance in Hong Kong Chinese adolescents with both obesity and non-alcoholic fatty liver disease (NAFLD).
methodsFifty two adolescents with obesity and NAFLD were analysed (14-18 years), stratified into fatty and non-fatty pancreas groups using chemical shift encoded MRI-pancreas proton density fat fraction ≥5%. Pancreatic, abdominal subcutaneous adipose tissue (SAT)/visceral adipose tissue (VAT) volumes, biochemical and anthropometric parameters were measured. Mann-Whitney U test, multiple linear/binary logistic regression analyses and odds ratios were used.
resultsFifty percent had fatty pancreas, 38% had metabolic syndrome and 81% had insulin resistance. Liver proton density fat fraction (PDFF) and VAT were independent predictors of insulin resistance (P = .006, .016). Pancreas and liver PDFF were both independent predictors of beta cells dysfunction (P = .015, .050) and metabolic syndrome (P = .021, .041). Presence of fatty pancreas in obesity was associated with insulin resistance (OR = 1.58, 95% CI = 0.39-6.4) and metabolic syndrome (OR = 1.70, 95% CI = 0.53-5.5).
conclusionA significant causal relationship exists between fatty pancreas, fatty liver, body fat and the risk of developing metabolic syndrome and insulin resistance. KEY POINTS: Fatty pancreas is a common finding in adolescents with obesity, with a prevalence rate of 50% in this study cohort. Liver PDFF and VAT are independent predictors of insulin resistance while pancreas PDFF and liver PDFF are independent predictors of both beta cells dysfunction and metabolic syndrome. Presence of fatty pancreas at imaging should not be considered as a benign finding but rather as an imaging biomarker of emerging pancreatic metabolic and endocrine dysfunction.
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