ArticleJournal of applied clinical medical physics2020
Impact of interfractional anatomical variation and setup correction methods on interfractional dose variation in IMPT and VMAT plans for pancreatic cancer patients: A planning study.
Article in Journal of applied clinical medical physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 14 citations in OpenAlex.
- Deep learning-based delineation of whole-body organs at risk empowering adaptive radiotherapy.BMC medical informatics and decision making · 2025Article
- Partial adaptation for online-adaptive proton therapy triggered by during-delivery treatment verification: Feasibility study on prostate cancer treatments.Physics and imaging in radiation oncology · 2025Article
- A systematic review of tumour position reproducibility and stability in breath-hold for radiation therapy of the upper abdomen.Physics and imaging in radiation oncology · 2025Review
- In vivo dosimetry for proton therapy: A Monte Carlo study of the Gadolinium spectral response throughout the course of treatment.Medical physics · 2025Article
- Investigation of interfractional range variation owing to anatomical changes with beam directions based on water equivalent thickness in proton therapy for pancreatic cancer.Journal of radiation research · 2024Article
- Online Adaptive MRI-Guided Stereotactic Body Radiotherapy for Pancreatic and Other Intra-Abdominal Cancers.Cancers · 2023Article
- Article
- Image guidance and interfractional anatomical variation in paediatric abdominal radiotherapy.The British journal of radiology · 2023Article
- Online adaptive planning methods for intensity-modulated radiotherapy.Physics in medicine and biology · 2023Review
- Deep learning based synthetic CT from cone beam CT generation for abdominal paediatric radiotherapy.Physics in medicine and biology · 2023Article
- Adaptive proton therapy.Physics in medicine and biology · 2021Review
- Dosimetric impact of simulated changes in large bowel content during proton therapy with simultaneous integrated boost for locally advanced pancreatic cancer.Journal of applied clinical medical physics · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate the impact of interfractional anatomical changes and setup correction methods on dose distributions in pancreatic cancer patients under breath-hold conditions.
methodsThree intensity-modulated proton therapy (IMPT) plans with different beam arrangements and one volumetric-modulated arc therapy (VMAT) plan prescribing 54 Gy in 30 fractions were created for 10 patients who underwent three additional CT scans performed at an interval of 1-2 weeks. The additional CT sets were rigidly registered to the simulation CT set using both bone-matching (BM) and organ-matching (OM) methods in each patient. Recalculated dose distributions and dose-volume indices on the additional CT sets using either the BM or the OM method were compared with the simulation values.
resultsDifferences in the gross tumor volume D
conclusionOrgan-matching may be a better setup correction technique than BM for both photon therapy and IMPT plans. However, in some beam arrangements of IMPT, the dose distribution may be somewhat worse using OM, due to interfractional anatomical variation. Therefore, it is important to choose beam angles that are less likely to be influenced by changes in the gastrointestinal gas volume, especially in IMPT plans.
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