ArticleThe New phytologist2020
Directional auxin fluxes in plants by intramolecular domain-domain coevolution of PIN auxin transporters.
Article in The New phytologist, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Benzoic acid inhibits peach root growth and lateral root emergence by disrupting auxin homeostasis through salicylic acid accumulation.Plant cell reports · 2026Article
- Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Control of leaf development in the water fern Ceratopteris richardii by the auxin efflux transporter CrPINMa in the CRISPR/Cas9 analysis.BMC plant biology · 2024Article
- Absence of SICKLE triggers programed cell death by disturbing alternative splicing and decay of mRNAs.Plant physiology · 2023Article
- SYNTAXIN OF PLANTS81 regulates root meristem activity and stem cell niche maintenance via ROS signaling.Plant physiology · 2023Article
- Developmental regulation of leaf venation patterns: monocot versus eudicots and the role of auxin.The New phytologist · 2022Review
- Potassium transporter TRH1/KUP4 contributes to distinct auxin-mediated root system architecture responses.Plant physiology · 2022Article
- Biological Functions of Strigolactones and Their Crosstalk With Other Phytohormones.Frontiers in plant science · 2022Review
- Characterization and expression profiling of PIN auxin efflux transporters reveal their role in developmental and abiotic stress conditions in rice.Frontiers in plant science · 2022Article
- Transport mechanisms of plant hormones.Current opinion in plant biology · 2021Review
- Genome-Wide Identification and Characterization of PIN-FORMED (PIN) Gene Family Reveals Role in Developmental and Various Stress Conditions inInternational journal of molecular sciences · 2021Article
- Magnesium Limitation Leads to Transcriptional Down-Tuning of Auxin Synthesis, Transport, and Signaling in the Tomato Root.Frontiers in plant science · 2021Article
- ER-Localized PIN Carriers: Regulators of Intracellular Auxin Homeostasis.Plants (Basel, Switzerland) · 2020Review
- Improvement of a Genetic Transformation System and Preliminary Study on the Function ofInternational journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphogenesis and adaptive tropic growth in plants depend on gradients of the phytohormone auxin, mediated by the membrane-based PIN-FORMED (PIN) auxin transporters. PINs localize to a particular side of the plasma membrane (PM) or to the endoplasmic reticulum (ER) to directionally transport auxin and maintain intercellular and intracellular auxin homeostasis, respectively. However, the molecular cues that confer their diverse cellular localizations remain largely unknown. In this study, we systematically swapped the domains between ER- and PM-localized PIN proteins, as well as between apical and basal PM-localized PINs from Arabidopsis thaliana, to shed light on why PIN family members with similar topological structures reside at different membrane compartments within cells. Our results show that not only do the N- and C-terminal transmembrane domains (TMDs) and central hydrophilic loop contribute to their differential subcellular localizations and cellular polarity, but that the pairwise-matched N- and C-terminal TMDs resulting from intramolecular domain-domain coevolution are also crucial for their divergent patterns of localization. These findings illustrate the complexity of the evolutionary path of PIN proteins in acquiring their plethora of developmental functions and adaptive growth in plants.
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