Evidence map›Paper›PMID 32350774›Full record

ArticleAIDS and behavior2020

Greater Levels of Self-Reported Adherence to Pre-Exposure Prophylaxis (PrEP) are Associated with Increased Condomless Sex Among Men Who Have Sex with Men.

Elizabeth C Pasipanodya, Michael J Li, Sonia Jain, Xiaoying Sun, Jessica Tobin, Eric Ellorin, Michael Dube, Eric S Daar, Katya Corado, Joel Milam and 4 more

Open access · greenAbstract read
In one paragraph

Article in AIDS and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.1field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pre-exposure Prophylaxis Adherence Among Men Who Have Sex With Men: A Systematic Review and Meta-analysis.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2024
    Pooled it
  2. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Elizabeth C PasipanodyaRehabilitation Research Center, Santa Clara Valley Medical Center, San Jose, CA, 95128, USA.
Michael J LiUCLA Center for HIV Identification, Prevention and Treatment Services (CHIPTS), Los Angeles, CA, 90024, USA.
Sonia JainDepartment of Family Medicine and Public Health, University of California San Diego, San Diego, CA, 92093, USA.
Xiaoying SunDepartment of Family Medicine and Public Health, University of California San Diego, San Diego, CA, 92093, USA.
Jessica TobinKeck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Eric EllorinDepartment of Family Medicine and Public Health, University of California San Diego, San Diego, CA, 92093, USA.
Michael DubeKeck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Eric S DaarLos Angeles Biomedical Research Institute At Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Katya CoradoThe Lundquist Institute, Torrance, CA, 90502, USA.
Joel MilamKeck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Jill BlumenthalDepartment of Family Medicine and Public Health, University of California San Diego, San Diego, CA, 92093, USA.
Sheldon H MorrisDepartment of Family Medicine and Public Health, University of California San Diego, San Diego, CA, 92093, USA.
David J MooreDepartment of Psychiatry, HIV Neurobehavioral Research Program, University of California San Diego, 220 Dickinson Street, Suite B, MC8231, San Diego, CA, 92103, USA. djmoore@ucsd.edu.
and the California Collaborative Treatment Group (CCTG)
University of Southern California · USUniversity of California San Diego · USSanta Clara Valley Medical Center · USThe Lundquist Institute · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4M
UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Nina Thawata Harawa · 1997 to 2026
$53.5M
Training grant for Cancer Control and EpidemiologyT32CA009492 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PENTZ, MARY ANN · 1985 to 2019
$7.4M
Postdoctoral Training in Global AIDS Prevention ResearchT32MH080634 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JESSE LAWTON CLARK, Pamina Mae Gorbach · 2007 to 2026
$6.4M
NCATS NIH HHS UL1 TR001442NCI NIH HHS T32 CA009492NIAID NIH HHS P30 AI036214NIMH NIH HHS P30 MH058107NIMH NIH HHS T32 MH080634
6 · The paper itself

Abstract

The effectiveness of pre-exposure prophylaxis (PrEP) against HIV acquisition depends on treatment adherence; however, within-person associations between levels of PrEP adherence and engagement in condomless sex have not been well studied. In the context of a demonstration project, 372 men who have sex with men received once-daily PrEP and completed six study visits over 48 weeks. Two-part growth mixture modeling was used to examine the longitudinal trajectory of condomless anal intercourse (CAI) and self-reports of PrEP adherence, controlling for relevant covariates. Over time, greater PrEP adherence was contemporaneously associated with both a higher likelihood of engaging in any CAI and with a greater number of CAI acts. Substance use was also associated with a higher likelihood of engaging in CAI. Contemporaneous associations between self-reported PrEP adherence and CAI suggest that adherence behaviors may be motivated by the desire to mitigate risk of HIV infection; however, exact directionality is unknown.

Indexed as

Drug MonitoringAdultAnti-HIV AgentsCondomsHIV InfectionsHomosexuality, MaleHumansMalePre-Exposure ProphylaxisSelf ReportSexual and Gender MinoritiesSexual BehaviorUnsafe SexYoung AdultAnti-HIV AgentsAdherenceCondomless sexHIVPrEPRisk compensation

Identifiers

PMID32350774
PMCPMC7508761
OpenAlexW3023436420

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.