Evidence map›Paper›PMID 32350530›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2020

Sex Differences in Functional Connectivity of the Salience, Default Mode, and Central Executive Networks in Youth with ASD.

Katherine E Lawrence, Leanna M Hernandez, Hilary C Bowman, Namita T Padgaonkar, Emily Fuster, Allison Jack, Elizabeth Aylward, Nadine Gaab, John D Van Horn, Raphael A Bernier and 9 more

Abstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Fractionation of sex differences in human cortical anatomy.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Katherine E LawrenceDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA.
Leanna M HernandezDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA.
Hilary C BowmanDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA.
Namita T PadgaonkarDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA.
Emily FusterDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA.
Allison JackAutism & Neurodevelopmental Disorders Institute, The George Washington University, Washington, DC 20052, USA.
Elizabeth AylwardCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington 98195, USA.
Nadine GaabDivision of Developmental Medicine, Department of Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
John D Van HornDepartment of Psychology, University of Virginia, Charlottesville, VA 22904, USA.
Raphael A BernierDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195, USA.
Daniel H GeschwindDepartment of Neurology and Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA.
James C McPartlandDepartment of Pediatrics, Yale School of Medicine, New Haven, CT 06520, USA.
Charles A NelsonDivision of Developmental Medicine, Department of Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Sara J WebbDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195, USA.
Kevin A PelphreyDepartment of Neurology, University of Virginia, Charlottesville, VA 22904, USA.
Shulamite A GreenDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA.
Susan Y BookheimerDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA.
Mirella DaprettoDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA.
GENDAAR Consortium

Funding

Multimodal Developmental Neurogenetics of Females with ASDR01MH100028 · NIMH · YALE UNIVERSITY · PI Allison Elizabeth Jack, LAUREN KENWORTHY · 2012 to 2026
$37.8M
Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI DANIEL DOHERTY · 2020 to 2026
$9.9M
Training Grant in Neurobehavioral GeneticsT32NS048004 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, OPHOFF, ROEL A · 2004 to 2025
$5.8M
AN INFORMATICS FACILITY FOR NEUROIMAGINGC06RR015431 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TOGA, ARTHUR W · 2000 to 2000
$2.0M
High Capacity Storage System for Computational BiologyS10OD011939 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOODS, ROGER P · 2012 to 2012
$598k
Gene-brain-environment interactions as determinants of typical and atypical developmental trajectoriesK00MH119663 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHARMA, LEANNA MARIE HERNANDEZ · 2018 to 2021
$325k
Gene-brain-environment interactions: Predicting social skill heterogeneity in ASDF32MH105167 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREEN, SHULAMITE ABRA · 2014 to 2017
$159k
Impact of Cumulative Genetic Risk on Brain Connectivity in ASDF31MH110140 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAWRENCE, KATHERINE E · 2016 to 2019
$110k
Gene-brain-environment interactions as determinants of typical and atypical developmental trajectoriesF99NS105206 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHARMA, LEANNA MARIE HERNANDEZ · 2017 to 2017
$39k
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR012169 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAZZIOTTA, JOHN C · 1996 to 1997
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NCRR NIH HHS C06 RR012169NCRR NIH HHS C06 RR015431NIH HHS S10 OD011939NIMH NIH HHS F31 MH110140NIMH NIH HHS F32 MH105167NIMH NIH HHS R01 MH100028NINDS NIH HHS F99 NS105206NINDS NIH HHS T32 NS048004
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is associated with the altered functional connectivity of 3 neurocognitive networks that are hypothesized to be central to the symptomatology of ASD: the salience network (SN), default mode network (DMN), and central executive network (CEN). Due to the considerably higher prevalence of ASD in males, however, previous studies examining these networks in ASD have used primarily male samples. It is thus unknown how these networks may be differentially impacted among females with ASD compared to males with ASD, and how such differences may compare to those observed in neurotypical individuals. Here, we investigated the functional connectivity of the SN, DMN, and CEN in a large, well-matched sample of girls and boys with and without ASD (169 youth, ages 8-17). Girls with ASD displayed greater functional connectivity between the DMN and CEN than boys with ASD, whereas typically developing girls and boys differed in SN functional connectivity only. Together, these results demonstrate that youth with ASD exhibit altered sex differences in these networks relative to what is observed in typical development, and highlight the importance of considering sex-related biological factors and participant sex when characterizing the neural mechanisms underlying ASD.

Indexed as

Sex CharacteristicsAdolescentAutism Spectrum DisorderBrainBrain MappingChildFemaleHumansMagnetic Resonance ImagingMaleNeural Pathwaysautism spectrum disorderfunctional connectivityresting-state functional magnetic resonance imagingsex differencessexual differentiation

Identifiers

PMID32350530
PMCPMC7391269

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.