ArticleNature2020
The mutational landscape of normal human endometrial epithelium.
Abstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 299 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
299citing papers in PubMed, 1 pooled it
27.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
299 citing papers in PubMed, 1 synthesis or guideline pooled it, 495 citations in OpenAlex.
- WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Homologous): homologous rodent models.Molecular human reproduction · 2025Pooled it
- Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women.Genome medicine · 2022Trial
- A single-cell lens into the co-evolution of genotypes and phenotypes in cancer.Nature reviews. Cancer · 2026Review
- Engineering the human endometrium at the intersection of development and reproduction.Nature biomedical engineering · 2026Review
- p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer-relevant paralog interplay.Molecular oncology · 2026Article
- Molecular signature of human endometrial stem/progenitor cells at the single-cell level.Stem cell reports · 2026Article
- Context-dependent selection sculpts mutational landscapes in the normal lung.Research square · 2026Article
- Diverse Onchocercidae from Malaysian cats and Indonesian macaques: Morphological and molecular analysis of individual microfilariae using mitochondrial genomes, 28S rRNA, and Wolbachia endosymbiont sequences.PLoS neglected tropical diseases · 2026Article
- The Tumor Multi-Omic Landscape of Endometrial Cancers Developed on a Background of Adiposity.Genes · 2026Article
- Individualised progesterone receptor modulator prevention strategies for triple-negative breast cancer in BRCA1 pathogenic variant carriers.NPJ breast cancer · 2026Review
- Age distinguishes selection from causation in cancer genomes.Nature genetics · 2026Article
- Comprehensive Molecular Characterization of High-Grade Endometrial Cancer in an Ancestrally Diverse Cohort.bioRxiv : the preprint server for biology · 2026Article
- Pancancer Fine-Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review
- Somatic mutations in endometrial epithelium: biological insights and emerging in vitro models.Molecular human reproduction · 2026Review
- Extracellular matrix: new insights into its role in female reproductive aging and potential therapeutic strategies.npj aging · 2026Review
- Somatic mutations and clonal evolution in normal tissues and cancer development.Experimental & molecular medicine · 2026Review
- Somatic mutations in cervicovaginal samples: assessing their role in ovarian cancer detection and prognosis.Translational oncology · 2026Article
- Telomere Crisis Shapes Cancer Evolution.Cold Spring Harbor perspectives in biology · 2026Review
- Review
239 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
25 authors at 7 institutions in 3 countries.
Luiza MooreCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0001-5315-516X
Daniel LeongamornlertCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.
Tim H H CoorensCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.
Mathijs A SandersCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.
Peter EllisCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.
Stefan C DentroCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.
Kevin J DawsonCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.
Tim ButlerCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0001-5803-1035
Raheleh RahbariCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-1839-7785
Thomas J MitchellCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0003-0761-9503
Francesco MauraCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.
Jyoti NangaliaCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.
Patrick S TarpeyCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.
Simon F BrunnerCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.
Henry Lee-SixCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0003-4831-8088
Yvette HooksCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.
Sarah MoodyCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.
Krishnaa T MahbubaniDepartment of Surgery, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-1327-2334
Mercedes Jimenez-LinanDepartment of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Jan J BrosensTommy's National Miscarriage Research Centre, Warwick Medical School, University of Warwick, Coventry, UK.ORCID http://orcid.org/0000-0003-0116-9329
Christine A Iacobuzio-DonahueDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-4672-3023
Inigo MartincorenaCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.
Kourosh Saeb-ParsyDepartment of Surgery, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-0633-3696
Peter J CampbellCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-3921-0510
Michael R StrattonCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Cambridge, UK. mrs@sanger.ac.uk.ORCID http://orcid.org/0000-0001-6035-153X
Wellcome Sanger Institute · GBCambridge University Hospitals NHS Foundation Trust · GBMemorial Sloan Kettering Cancer Center · USUniversity of Cambridge · GBErasmus MC · NLEuropean Bioinformatics Institute · GBUniversity of Warwick · GB
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MCancer Research UK 21777Cancer Research UK 23917Cancer Research UK 27114Cancer Research UK 27176
Abstract
All normal somatic cells are thought to acquire mutations, but understanding of the rates, patterns, causes and consequences of somatic mutations in normal cells is limited. The uterine endometrium adopts multiple physiological states over a lifetime and is lined by a gland-forming epithelium
Indexed as
DNA Mutational AnalysisHealthMutationAdultAgedAged, 80 and overAge of OnsetAgingCarcinogenesisClone CellsEndometrial NeoplasmsEndometriumEpithelial CellsEpitheliumFemaleHumans
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.