ArticleScientific reports2020
Multi-layered Free-form 3D Cell-printed Tubular Construct with Decellularized Inner and Outer Esophageal Tissue-derived Bioinks.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Engineering Strain-Stiffening Granular Hydrogels for 3D-Printed Tissue-Mimicry.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Esophagus extracellular matrix with microenvironmental complexity for esophageal organoids.Bioactive materials · 2026Article
- Establishing a rabbit sham model of cervical esophageal surgery for circumferential esophageal transplantation.Clinical transplantation and research · 2026Article
- Bioengineered Approaches for Esophageal Regeneration: Advancing Esophageal Cancer Therapy.Bioengineering (Basel, Switzerland) · 2025Review
- Strategic Implementation of Multimaterial Additive Manufacturing: Bridging Research and Real-World Applications.ACS omega · 2025Review
- Article
- Understanding the cellular dynamics, engineering perspectives and translation prospects in bioprinting epithelial tissues.Bioactive materials · 2025Review
- Recent Advances in the Application of 3D-Printing Bioinks Based on Decellularized Extracellular Matrix in Tissue Engineering.ACS omega · 2024Review
- Advances in 3D bioprinting for urethral tissue reconstruction.Trends in biotechnology · 2024Review
- Dragging 3D printing technique controls pore sizes of tissue engineered blood vessels to induce spontaneous cellular assembly.Bioactive materials · 2024Article
- A 5 + 1-Axis 3D Printing Platform for Producing Customized Intestinal Fistula Stents.3D printing and additive manufacturing · 2023Article
- Pulp-Dentin Complex Regeneration with Cell Transplantation Technique Using Stem Cells Derived from Human Deciduous Teeth: Histological and Immunohistochemical Study in Immunosuppressed Rats.Bioengineering (Basel, Switzerland) · 2023Article
- Tissue Engineering for Gastrointestinal and Genitourinary Tracts.International journal of molecular sciences · 2022Review
- Bio-Engineered Scaffolds Derived from Decellularized Human Esophagus for Functional Organ Reconstruction.Cells · 2022Article
- Development of Bio-artificial Esophageal Tissue Engineering Utilization for Circumferential Lesion Transplantation: A Narrative Review.Iranian journal of medical sciences · 2022Review
- Decellularized esophageal tubular scaffold microperforated by quantum molecular resonance technology and seeded with mesenchymal stromal cells for tissue engineering esophageal regeneration.Frontiers in bioengineering and biotechnology · 2022Article
- Anatomical Engineering and 3D Printing for Surgery and Medical Devices: International Review and Future Exponential Innovations.BioMed research international · 2022Review
- Emerging Technologies in Multi-Material Bioprinting.Advanced materials (Deerfield Beach, Fla.) · 2021Review
- Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations.International journal of molecular sciences · 2021Review
- Total Meniscus Reconstruction Using a Polymeric Hybrid-Scaffold: Combined with 3D-Printed Biomimetic Framework and Micro-Particle.Polymers · 2021Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidences of various esophageal diseases (e.g., congenital esophageal stenosis, tracheoesophageal fistula, esophageal atresia, esophageal cancer) are increasing, but esophageal tissue is difficult to be recovered because of its weak regenerative capability. There are no commercialized off-the-shelf alternatives to current esophageal reconstruction and regeneration methods. Surgeons usually use ectopic conduit tissues including stomach and intestine, presumably inducing donor site morbidity and severe complications. To date, polymer-based esophageal substitutes have been studied as an alternative. However, the fabrication techniques are nearly limited to creating only cylindrical outer shapes with the help of additional apparatus (e.g., mandrels for electrospinning) and are unable to recapitulate multi-layered characteristic or complex-shaped inner architectures. 3D bioprinting is known as a suitable method to fabricate complex free-form tubular structures with desired pore characteristic. In this study, we developed a extrusion-based 3D printing technique to control the size and the shape of the pore in a single extrusion process, so that the fabricated structure has a higher flexibility than that fabricated in the conventional process. Based on this suggested technique, we developed a bioprinted 3D esophageal structure with multi-layered features and converged with biochemical microenvironmental cues of esophageal tissue by using decellularizedbioinks from mucosal and muscular layers of native esophageal tissues. The two types of esophageal tissue derived-decellularized extracellular matrix bioinks can mimic the inherent components and composition of original tissues with layer specificity. This structure can be applied to full-thickness circumferential esophageal defects and esophageal regeneration.
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