ArticleScientific reports2020
Fuzziness of muscle synergies in patients with multiple sclerosis indicates increased robustness of motor control during walking.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Muscle synergies and metabolic adaptations during perturbed walking in older adults.Scientific reports · 2025Article
- Multiple Sclerosis Classification Using the Local Divergence Exponent: Parameters Selection for State-Space Reconstruction.Sensors (Basel, Switzerland) · 2025Article
- Comparative analysis of muscle synergies in gait of stroke patients and healthy controls.Frontiers in human neuroscience · 2025Article
- Sex-specific trunk movement coordination in participants with low-back pain and asymptomatic controls.Frontiers in sports and active living · 2025Article
- Postural control of sway dynamics on an unstable surface reduces similarity in activation patterns of synergistic lower leg muscles.Frontiers in sports and active living · 2025Article
- Multimodal Neuroimaging and Electrophysiological Markers in Multiple Sclerosis: An Integrative Review of fMRI, EEG, and EMG Approaches : fMRI, EEG, EMG in Multiple Sclerosis.Galen medical journal · 2025Review
- Increased trial-to-trial similarity and reduced temporal overlap of muscle synergy activation coefficients manifest during learning and with increasing movement proficiency.Scientific reports · 2024Article
- Spatiotemporal modulation of a common set of muscle synergies during unpredictable and predictable gait perturbations in older adults.The Journal of experimental biology · 2024Article
- Muscle synergies inherent in simulated hypogravity running reveal flexible but not unconstrained locomotor control.Scientific reports · 2024Article
- Observational
- Association of daily physical activity with brain volumes and cervical spinal cord areas in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Muscle spindles and their role in maintaining robust locomotion.The Journal of physiology · 2023Review
- Sex-specific tuning of modular muscle activation patterns for locomotion in young and older adults.PloS one · 2022Article
- Improvement in gait stability in older adults after ten sessions of standing balance training.PloS one · 2022Article
- Proactive Modulation in the Spatiotemporal Structure of Muscle Synergies Minimizes Reactive Responses in Perturbed Landings.Frontiers in bioengineering and biotechnology · 2021Article
- Lower complexity of motor primitives ensures robust control of high-speed human locomotion.Heliyon · 2020Article
- Reliability and Repeatability Analysis of Indices to Measure Gait Deterioration in MS Patients during Prolonged Walking.Sensors (Basel, Switzerland) · 2020Article
- Improved Gait of Persons With Multiple Sclerosis After Rehabilitation: Effects on Lower Limb Muscle Synergies, Push-Off, and Toe-Clearance.Frontiers in neurology · 2020Article
- Muscle Synergies in Patients With Multiple Sclerosis Reveal Demand-Specific Alterations in the Modular Organization of Locomotion.Frontiers in human neuroscience · 2020Article
- Neuromechanics of Dynamic Balance Tasks in the Presence of Perturbations.Frontiers in human neuroscience · 2020Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deficits during gait poses a significant threat to the quality of life in patients with Multiple Sclerosis (MS). Using the muscle synergy concept, we investigated the modular organization of the neuromuscular control during walking in MS patients compared to healthy participants (HP). We hypothesized a widening and increased fuzziness of motor primitives (e.g. increased overlap intervals) in MS patients compared to HP allowing the motor system to increase robustness during walking. We analysed temporal gait parameters, local dynamic stability and muscle synergies from myoelectric signals of 13 ipsilateral leg muscles using non-negative matrix factorization. Compared to HP, MS patients showed a significant decrease in the local dynamic stability of walking during both, preferred and fixed (0.7 m/s) speed. MS patients demonstrated changes in time-dependent activation patterns (motor primitives) and alterations of the relative muscle contribution to the specific synergies (motor modules). We specifically found a widening in three out of four motor primitives during preferred speed and in two out of four during fixed speed in MS patients compared to HP. The widening increased the fuzziness of motor control in MS patients, which allows the motor system to increase its robustness when coping with pathology-related motor deficits during walking.
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