Evidence map›Paper›PMID 32350199›Full record

ArticleInternal medicine (Tokyo, Japan)2020

Two Cases of Hepatocellular Carcinoma Arising Over 20 Years after a Sustained Virologic Response Following Interferon Therapy for Chronic Hepatitis C.

Kazuhide Takata, Fuminori Ishii, Yotaro Uchida, Hiromi Fukuda, Ryo Yamauchi, Kaoru Umeda, Naoaki Tsuchiya, Takashi Tanaka, Keiji Yokoyama, Daisuke Morihara and 4 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Kazuhide TakataDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Fuminori IshiiDepartment of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, Japan.
Yotaro UchidaDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Hiromi FukudaDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Ryo YamauchiDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Kaoru UmedaDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Naoaki TsuchiyaDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Takashi TanakaDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Keiji YokoyamaDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Daisuke MoriharaDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Yasuaki TakeyamaDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Satoshi ShakadoDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Shotaro SakisakaDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Fumihito HiraiDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Fukuoka University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of hepatocellular carcinoma (HCC) after a sustained virologic response (SVR) due to interferon (IFN) therapy for hepatitis C virus infection remains a serious problem. We herein report 2 cases of HCC that developed more than 20 years after SVR with IFN therapy for chronic hepatitis C. The patients were 89- and 72-year-old men with HCC that developed 24-25 years after an SVR with IFN therapy. These patients regularly underwent imaging examinations; therefore, the HCC was detected in the early stage, when it was still curable. Both cases suggest that long-term surveillance after an SVR is effective for the detection of HCC, and radical treatment is possible.

Indexed as

AgedAged, 80 and overAntiviral AgentsCarcinoma, HepatocellularHepatitis C, ChronicHumansInterferonsLiver NeoplasmsMaleSustained Virologic ResponseAntiviral AgentsInterferonshepatocellular carcinomainterferon therapysustained virologic response

Identifiers

PMID32350199
PMCPMC7474997
OpenAlexW3021498960

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.